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Frequency and Outcomes of Ipsilateral Axillary Lymphadenopathy After COVID-19 Vaccination

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Ipsilateral axillary lymphadenopathy (IAL) after COVID-19 vaccination results in diagnostic conundrums.13 Expert guidelines advise IAL management based on patient symptoms, imaging results, and risk factors.2,4,5 We report on the frequency and outcomes of breast imaging–identified IAL after recent COVID-19 vaccination.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: April 22, 2022.

Published: June 8, 2022. doi:10.1001/jamanetworkopen.2022.16172

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Zhou W et al. JAMA Network Open.

Corresponding Author: Wenhui Zhou, MD, PhD, Department of Radiology, Stanford University Medical Center, 300 Pasteur Dr, H1330, MC: 5621, Stanford, CA 94305 (wzhou02@stanford.edu).

Author Contributions: Dr Zhou had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: Zhou, DeMartini.

Drafting of the manuscript: Zhou, DeMartini.

Critical revision of the manuscript for important intellectual content: Zhou, Ikeda.

Statistical analysis: Zhou.

Administrative, technical, or material support: Zhou, Ikeda.

Conflict of Interest Disclosures: Dr DeMartini reported receiving personal fees from Kheiron Medical Technologies and grants from Whiterabbit.ai outside the submitted work. Dr Ikeda reported serving as a consultant for Hologic Inc, holding stock in Moderna and Pfizer, and serving as a lecturer for postgraduate CME radiology courses for CME Science outside the submitted work. No other disclosures were reported.

References
1.
Robinson  KA , Maimone  S , Gococo-Benore  DA , Li  Z , Advani  PP , Chumsri  S .  Incidence of axillary adenopathy in breast imaging after COVID-19 vaccination.   JAMA Oncol. 2021;7(9):1395-1397. doi:10.1001/jamaoncol.2021.3127 PubMedGoogle ScholarCrossref
2.
Becker  AS , Perez-Johnston  R , Chikarmane  SA ,  et al.  Multidisciplinary recommendations regarding post-vaccine adenopathy and radiologic imaging: Radiology scientific expert panel.   Radiology. 2021;300(2):E323-E327. doi:10.1148/radiol.2021210436 PubMedGoogle ScholarCrossref
3.
Igual-Rouilleault  AC , Soriano  I , Quan  PL , Fernández-Montero  A , Elizalde  A , Pina  L .  Unilateral axillary adenopathy induced by COVID-19 vaccine: US follow-up evaluation.   Eur Radiol. 2022;32(5):3199-3206. doi:10.1007/s00330-021-08309-7 PubMedGoogle ScholarCrossref
4.
Grimm  L , Srini  A , Dontchos  B . Revised SBI recommendations for the management of axillary adenopathy in patients with recent COVID-19 vaccination. 2022. Society of Breast Imaging. Accessed April 6, 2022. https://www.sbi-online.org/Portals/0/Position Statements/2022/SBI-recommendations-for-managing-axillary-adenopathy-post-COVID-vaccination_updatedFeb2022.pdf
5.
Schiaffino  S , Pinker  K , Magni  V ,  et al.  Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging (EUSOBI).   Insights Imaging. 2021;12(1):119. doi:10.1186/s13244-021-01062-x PubMedGoogle ScholarCrossref
6.
Lehman  CD , D’Alessandro  HA , Mendoza  DP , Succi  MD , Kambadakone  A , Lamb  LR .  Unilateral lymphadenopathy after COVID-19 vaccination: a practical management plan for radiologists across specialties.   J Am Coll Radiol. 2021;18(6):843-852. doi:10.1016/j.jacr.2021.03.001 PubMedGoogle ScholarCrossref
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