The US Food and Drug Administration (FDA) first approved a medication abortion regimen in 2000, which consisted of mifepristone (a progesterone antagonist that causes pregnancy tissue to detach from the endometrium) and misoprostol (a prostaglandin that induces cervical softening and uterine contractions). Current evidence-based regimens still rely on this drug combination, which is approved for abortions up to 10 weeks’ gestational age. In 2017 in the US, medication abortions accounted for an estimated 60% of abortions at less than 10 weeks’ gestation.1
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Corresponding Author: Stephanie B. Teal, MD, MPH, 11100 Euclid Ave, MAC 5034, Cleveland, OH 44106 (Stephanie.Teal@UHhospitals.org).
Published Online: June 2, 2022. doi:10.1001/jama.2022.6344
Conflict of Interest Disclosures: None reported.
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