Accepted for Publication: April 22, 2022.
Published: June 9, 2022. doi:10.1001/jamanetworkopen.2022.16349
Open Access: This is an open access article distributed under the terms of the CC-BY-NC-ND License. © 2022 Bondar J et al. JAMA Network Open.
Corresponding Author: Adam M. Chekroud, PhD, Department of Psychiatry, Yale University, New Haven, CT 06511 (adam.chekroud@yale.edu).
Author Contributions: Dr Bondar and Ms Babich Morrow had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of analysis. Dr Bondar and Ms Babich Morrow contributed equally to the manuscript.
Concept and design: Bondar, Babich Morrow, Brown, Krystal, Chekroud.
Acquisition, analysis, or interpretation of data: Bondar, Babich Morrow, Gueorguieva, Hawrilenko, Krystal, Corlett, Chekroud.
Drafting of the manuscript: Bondar, Babich Morrow, Hawrilenko, Corlett, Chekroud.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Bondar, Babich Morrow, Gueorguieva, Hawrilenko, Krystal, Chekroud.
Obtained funding: Krystal, Chekroud.
Administrative, technical, or material support: Babich Morrow, Brown, Krystal, Chekroud.
Supervision: Brown, Chekroud.
Conflict of Interest Disclosures: Dr Bondar and Ms Babich Morrow reported being employed by and holding equity in Spring Care. Dr Gueorguieva reported receiving royalties from the book Statistical Methods in Psychiatry and Related Fields published by CRC Press and being an inventor on US patent application 20200143922. Drs Brown and Hawrilenko reported being employed by and holding equity in Spring Care. Dr Krystal reported being a consultant for Aptinyx Inc; Atai Life Sciences; AstraZeneca Pharmaceuticals; Biogen Idec; Biomedisyn Corporation; Bionomics Limited (Australia); Boehringer Ingelheim International; Cadent Therapeutics Inc; Clexio Bioscience Ltd; COMPASS Pathways Limited, United Kingdom; Concert Pharmaceuticals Inc; Epiodyne Inc; EpiVario Inc; Greenwich Biosciences Inc; Heptares Therapeutics Limited (UK); Janssen Research & Development; Jazz Pharmaceuticals Inc; Otsuka America Pharmaceutical Inc; Perception Neuroscience Holdings Inc; Spring Care Inc; Sunovion Pharmaceuticals Inc; Takeda Industries; Taisho Pharmaceutical Co Ltd; being on the scientific advisory board of Biohaven Pharmaceuticals; BioXcel Therapeutics Inc; Cadent Therapeutics Inc; Cerevel Therapeutics LLC; EpiVario Inc; Eisai Inc; Jazz Pharmaceuticals Inc; Lohocla Research Corporation; Novartis Pharmaceuticals Corporation; PsychoGenics Inc; RBNC Therapeutics Inc; Spring Care Inc; Tempero Bio Inc; Terran Biosciences Inc; holding stock in Biohaven Pharmaceuticals; Sage Pharmaceuticals; Spring Care Inc; having stock options in Biohaven Pharmaceuticals Medical Sciences; EpiVario Inc; RBNC Therapeutics Inc; Terran Biosciences Inc; Tempero Bio Inc; being an inventor on 9 patents (patent numbers 5447948, 8778979, 9592207; patent application numbers 15379013, 61973961, 62444552, 62719935, 63/125,181; and USPTO docket number Y0087.70116US00); being an editor of Biological Psychiatry and receiving research support from AstraZeneca Pharmaceuticals and Novartis (both provide drugs for research related to NIAAA grant “Center for Translational Neuroscience of Alcoholism [CTNA-4]”). Dr Chekroud reported holding equity in Spring Care; Carbon Health Technologies Inc; Wheel Health Inc; Parallel Technologies Inc; Healthie Inc; and UnitedHealthcare; being the lead inventor on 3 patent submissions relating to treatment for major depressive disorder (US Patent and Trademark Office docket number Y0087.70116US00 and provisional application numbers 62/491 660 and 62/629 041); having done paid consultancy for Fortress Biotech about antidepressant drug development; and providing unpaid advisory services to health care technology startups. No other disclosures were reported.
Additional Contributions: Jessica Streeter, PhD (Spring Health), provided guidance on employee retention analysis. Dr Streeter receives a salary and holds equity.