Updated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Estimates Based on Blood Donations, July 2020-December 2021 | Infectious Diseases | JN Learning | AMA Ed Hub [Skip to Content]
[Skip to Content Landing]

Updated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Estimates Based on Blood Donations, July 2020-December 2021

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

By testing for both SARS-CoV-2 spike and nucleocapsid antibodies, seroprevalence studies can estimate the proportion of a population with antibodies from previous infection (nucleocapsid antibody or infection-induced seroprevalence) and from infection or vaccination (spike antibody or combined infection- and vaccine-induced seroprevalence). US seroprevalence from July 2020 to May 2021 based on blood donations was reported previously.1 This report includes monthly estimates through the conclusion of the study in December 2021.

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 CME Credit™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: May 24, 2022.

Published Online: June 13, 2022. doi:10.1001/jama.2022.9745

Corresponding Author: Jefferson M. Jones, MD, MPH, Centers for Disease Control and Prevention, MS V18-4, 1600 Clifton Rd NE, Atlanta, GA 30329-4027 (ioe8@cdc.gov).

Author Contributions: Dr Opsomer had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Jones, Stone, Stramer, Busch.

Acquisition, analysis, or interpretation of data: Jones, Opsomer, Stone, Benoit, Ferg, Stramer, Busch.

Drafting of the manuscript: Jones, Opsomer, Stramer, Busch.

Critical revision of the manuscript for important intellectual content: Jones, Stone, Benoit, Ferg, Stramer, Busch.

Statistical analysis: Opsomer, Ferg, Busch.

Obtained funding: Jones, Stone, Busch.

Administrative, technical, or material support: Jones, Stone, Benoit, Stramer, Busch.

Supervision: Jones, Stone, Stramer, Busch.

Conflict of Interest Disclosures: Dr Stramer reported receiving a contract from the Centers for Disease Control and Prevention (CDC) via Vitalant Research Institute outside the submitted work. Dr Busch reported being an employee of Vitalant Research Institute and serving on the medical advisory board for Creative Testing Systems; Vitalant Research Institute receives research funds and reagents for studies from Ortho and Roche and Dr Busch has presented on behalf of both companies at meetings, with travel support, but does not receive personal compensation from these or other SARS-CoV-2 test-manufacturing companies. No other disclosures were reported.

Funding/Support: This study was funded by the CDC.

Role of the Funder/Sponsor: CDC employees contributed to the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The CDC did not have the right to veto publication or to control the decision regarding to which journal the study was submitted.

Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC.

Additional Contributions: We thank Dane Freeman, PhD, Georgia Tech Research Institute, for graphic assistance; he was compensated for his role in the study. We thank members from Vitalant Research Institute, Westat, American Red Cross, Georgia Tech Research Institute, all participating blood collection organizations, and all testing laboratories for their assistance on this project (see Supplement for organization and names of the National Blood Donor Seroprevalence Study team). Finally, we thank all blood donors who contributed to this study.

References
1.
Jones  JM , Stone  M , Sulaeman  H ,  et al.  Estimated US infection- and vaccine-induced SARS-CoV-2 seroprevalence based on blood donations, July 2020-May 2021.   JAMA. 2021;326(14):1400-1409. doi:10.1001/jama.2021.15161PubMedGoogle ScholarCrossref
2.
Centers for Disease Control and Prevention. COVID data tracker. Accessed March 23, 2022. https://covid.cdc.gov/covid-data-tracker
3.
Fan  Y , Li  X , Zhang  L , Wan  S , Zhang  L , Zhou  F .  SARS-CoV-2 Omicron variant: recent progress and future perspectives.   Signal Transduct Target Ther. 2022;7(1):141. doi:10.1038/s41392-022-00997-xPubMedGoogle ScholarCrossref
4.
Ferdinands  JM , Rao  S , Dixon  BE ,  et al.  Waning 2-dose and 3-dose effectiveness of mRNA vaccines against COVID-19–associated emergency department and urgent care encounters and hospitalizations among adults during periods of Delta and Omicron variant predominance—VISION Network, 10 states, August 2021-January 2022.   MMWR Morb Mortal Wkly Rep. 2022;71(7):255-263. doi:10.15585/mmwr.mm7107e2PubMedGoogle ScholarCrossref
5.
Hall  V , Foulkes  S , Insalata  F ,  et al; SIREN Study Group.  Protection against SARS-CoV-2 after Covid-19 vaccination and previous infection.   N Engl J Med. 2022;386(13):1207-1220. doi:10.1056/NEJMoa2118691PubMedGoogle ScholarCrossref
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Close

Lookup An Activity

or

Close

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close