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The Human Acellular Vessel for Vascular Reconstruction or BypassA Novel Biologic Conduit for Vascular Bypass and Repair

To identify the key insights or developments described in this article
1 Credit CME

The Human Acellular Vessel (HAV) (Humacyte Inc) is a new biologic vascular conduit developed using regenerative medicine technology. Human vascular smooth muscle cells derived from US Food and Drug Administration (FDA)–registered tissue donors are isolated, expanded in culture, and seeded onto a biodegradable, polyglycolic acid mesh scaffold. The scaffolds are maintained within bioreactors and the developing vessels undergo pulsatile, cyclic distension for 8 weeks. The scaffold degrades and the newly formed extracellular matrix, including collagens type I and III, fibronectin, and vitronectin, is decellularized to remove immunogenic material while preserving the new vessel’s structure, tensile strength, and durability (Figure, A).14

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Article Information

Corresponding Author: Todd E. Rasmussen, MD, Mayo Clinic, Department of Surgery, Rochester, MN 55905 (rasmussen.todd@mayo.edu).

Published Online: June 22, 2022. doi:10.1001/jamasurg.2022.1214

Conflict of Interest Disclosures: Dr Rasmussen reported personal fees from Humacyte for clinical consultation outside the submitted work. No other disclosures were reported.

References
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