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Association Between BNT162b2 Vaccination and Long COVID After Infections Not Requiring Hospitalization in Health Care Workers

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Survivors of COVID-19 may present with long-lasting symptoms.1 Some factors have been associated with the development of post-COVID conditions (also referred to as “long COVID”),2 including hospitalization.3 A study of older US veterans showed 15% reduction of long COVID after vaccination; however, study limitations included the low number of women and suboptimal vaccination schedules.4

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Article Information

Accepted for Publication: June 22, 2022.

Published Online: July 1, 2022. doi:10.1001/jama.2022.11691

Corresponding Author: Maria Rescigno, PhD, Humanitas University, Via Rita Levi Montalcini, 4, 20072 Pieve Emanuele (MI), Italy (maria.rescigno@hunimed.eu).

Author Contributions: Dr Rescigno had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Azzolini and Levi contributed equally.

Concept and design: Azzolini, Mantovani, Rescigno.

Acquisition, analysis, or interpretation of data: Azzolini, Levi, Sarti, Pozzi, Mollura, Rescigno.

Drafting of the manuscript: Levi, Sarti, Mollura, Rescigno.

Critical revision of the manuscript for important intellectual content: Azzolini, Sarti, Pozzi, Mantovani, Rescigno.

Statistical analysis: Levi, Sarti, Mollura.

Obtained funding: Rescigno.

Supervision: Azzolini, Pozzi, Mantovani, Rescigno.

Conflict of Interest Disclosures: Dr Mantovani reported receiving personal fees for lectures from Ventana, Novartis, and Roche; consulting fees from Pierre Fabre, Verily, AbbVie, AstraZeneca, Third Rock Venture, and Merck; serving on the advisory board for Verseau Therapeutics, Myeloid Therapeutics, Imcheck Therapeutics, Ellipses, Olatec Therapeutics, Macrophage Pharma, Biovelocita, Principia, and Biolegend; grants from Novartis; and royalties for sale of reagents from Biolegend Royalties, Cedarlane Laboratories, HyCult Biotechnology, eBioscience Royalties, ABCAM Plc, Novus Biologicals, Enzo Life, and Affymetric. Dr Mantovani also reported having a patent for antihuman migration stimulating factor (MSF), a patent for NK or T cells and uses thereof, a patent for "use of SAP for the treatment of Euromycetes fungi infections,” and a patent for PTX3 as prognostic marker in COVID-19 licensed to Diasorin (prospective trial in sepsis underway). Dr Rescigno reported serving on the advisory board (with compensation) for MillBo and receiving grants from AlfaSigma, Gelesis, and Diasorin outside the submitted work. No other disclosures were reported.

Funding/Support: Fondazione Humanitas per la Ricerca funded this research.

Role of the Funder/Sponsor: Fondazione Humanitas per la Ricerca did not participate in any of the following: design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Additional Contributions: Valeria Cento, MD, PhD, Humanitas University, Daniele Braga, PhD, IRCCS Humanitas Research Hospital, and Riccardo Barbieri, PhD, Politecnico di Milano, have contributed to the study by helping with interpretation of the data or methodologically. None received compensation for their roles.

References
1.
Groff  D , Sun  A , Ssentongo  AE ,  et al.  Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection: a systematic review.   JAMA Netw Open. 2021;4(10):e2128568. doi:10.1001/jamanetworkopen.2021.28568PubMedGoogle ScholarCrossref
2.
Su  Y , Yuan  D , Chen  DG ,  et al; ISB-Swedish COVID-19 Biobanking Unit.  Multiple early factors anticipate post-acute COVID-19 sequelae.   Cell. 2022;185(5):881-895.e20. doi:10.1016/j.cell.2022.01.014PubMedGoogle ScholarCrossref
3.
Chen  C , Haupert  SR , Zimmermann  L , Shi  X , Fritsche  LG , Mukherjee  B .  Global prevalence of post COVID-19 condition or long COVID: a meta-analysis and systematic review.   J Infect Dis. Published online April 16, 2022. doi:10.1093/infdis/jiac136PubMedGoogle ScholarCrossref
4.
Al-Aly  Z , Bowe  B , Xie  Y .  Long COVID after breakthrough SARS-CoV-2 infection.   Nat Med. Published online May 25, 2022. doi:10.1038/s41591-022-01840-0PubMedGoogle ScholarCrossref
5.
Levi  R , Azzolini  E , Pozzi  C ,  et al.  One dose of SARS-CoV-2 vaccine exponentially increases antibodies in individuals who have recovered from symptomatic COVID-19.   J Clin Invest. 2021;131(12):149154. doi:10.1172/JCI149154PubMedGoogle ScholarCrossref
6.
Darwich  A , Pozzi  C , Fornasa  G ,  et al; ICH COVID-19 Task-force.  BNT162b2 vaccine induces antibody release in saliva: a possible role for mucosal viral protection?   EMBO Mol Med. 2022;14(5):e15326. doi:10.15252/emmm.202115326PubMedGoogle ScholarCrossref
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