Accepted for Publication: June 1, 2022.
Published Online: July 27, 2022. doi:10.1001/jamapsychiatry.2022.1973
Corresponding Author: Jordan W. Smoller, MD, ScD, 185 Cambridge St, 6th Floor, Boston, MA 02114 (firstname.lastname@example.org).
Author Contributions: Dr Lee had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Lee, Fatori, Brunoni, Smoller.
Acquisition, analysis, or interpretation of data: Lee, Liu, J. Bauermeister, Luh, Clark, S. Bauermeister, Smoller.
Drafting of the manuscript: Lee, Brunoni, Smoller.
Critical revision of the manuscript for important intellectual content: Lee, Liu, Fatori, J. Bauermeister, Luh, Clark, S. Bauermeister, Smoller.
Statistical analysis: Lee, Liu, Fatori, S. Bauermeister.
Administrative, technical, or material support: Lee, J. Bauermeister, Luh, Brunoni, Smoller.
Supervision: Clark, Brunoni, Smoller.
Conflict of Interest Disclosures: Dr Smoller reported grants from International HundredK+ Cohort Consortium during the conduct of the study and honoraria from Biogen and Tempus Labs, serving on scientific advisory boards for Sensorium Therapeutics and Leon Levy Foundation, and serving as principal investigator for a collaborative study sponsored by 23andMe of the genetics of depression and bipolar disorder (for which 23andMe provides analysis time as in-kind support but no payments) outside the submitted work. No other disclosures were reported.
Funding/Support: The All of Us Research Program is supported by grants through the National Institutes of Health, Office of the Director: Regional Medical Centers (1 OT2 OD026549, 1 OT2 OD026554, 1 OT2 OD026557, 1 OT2 OD026556, 1 OT2 OD026550, 1 OT2 OD026552, 1 OT2 OD026553, 1 OT2 OD026548, 1 OT2 OD026551, 1 OT2 OD026555, IAA AOD 16037); Federally Qualified Health Centers (HHSN 263201600085U); Data and Research Center (5 U2C OD023196); Biobank (1 U24 OD023121); The Participant Center (U24 OD023176); Participant Technology Systems Center (1 U24 OD023163); Communications and Engagement (3 OT2 OD023205; 3 OT2 OD023206); and Community Partners (1 OT2 OD025277, 3 OT2 OD025315, 1 OT2 OD025337, 1 OT2 OD025276). In addition to the funded partners, the All of Us Research Program would not be possible without the contributions made by its participants. All authors are supported by the International HundredK+ Cohorts Consortium (IHCC), which has been created in collaboration with the Global Alliance for Genomics and Health (GA4GH) and the Global Genomics Medicine Collaborative (G2MC) with support from the National Institutes of Health and the Wellcome Trust. In addition, Mr Bauermeister and Dr Bauermeister are supported by Dementias Platform UK (DPUK) funded by the Medical Research Council (MR/T0333771). Dr Smoller is supported in part by a gift from the Demarest Lloyd Jr, Foundation.
Role of the Funder/Sponsor: The IHCC reviewed and approved the manuscript but had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation of the manuscript; and decision to submit the manuscript for publication. All other funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank Nhi-Ha Trinh, MD, MPH, Massachusetts General Hospital, for her valuable input to this article.
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