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Booster doses of mRNA COVID-19 vaccines are administered worldwide to enhance antibody levels and immunity against Delta, Omicron, and emerging variants. Data on adverse events show a favorable safety profile, with similar reactogenicity for second and third doses. However, safety in older adults in long-term care (LTC) settings has not been well described.1,2 We examined adverse events following mRNA booster vaccination in LTC residents within the context of factors unique to the province of Quebec that may increase reactogenicity: extended interval between doses 1 and 2,3 heterologous vaccination, full dose mRNA-1273 (100 µg) booster,4 and high prevalence of previous COVID-19 infection.5
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: June 6, 2022.
Published: July 21, 2022. doi:10.1001/jamanetworkopen.2022.23401
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Zhang XS et al. JAMA Network Open.
Corresponding Author: Quoc Dinh Nguyen, MD, MPH, PhD, Division of Geriatrics, Department of Medicine, Centre hospitalier de l’Université de Montréal, 1000 rue Saint-Denis, Montreal, QC H2X 0C1, Canada (email@example.com).
Author Contributions: Dr Nguyen had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Zhang, Moreau, Nguyen.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Nguyen.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Nguyen.
Administrative, technical, or material support: Zhang, Moreau, Cruz-Santiago, Nguyen.
Supervision: Zhang, Moreau, Nguyen.
Conflict of Interest Disclosures: None reported.
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