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Therapy for Mild to Moderate Asthma

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Asthma is a disease characterized by recurring, reversible airways obstruction due to underlying inflammation and bronchial hyperresponsiveness. Asthma is one of the most common chronic noncommunicable diseases, affects an estimated 260 million people globally, and is associated with significant morbidity and mortality.1 Asthma with usually mild or infrequent symptoms (50%-75% of patients with asthma) contributes to 30% to 40% of exacerbations leading to emergency care; asthma-related death may occur in persons with asthma that is usually mild.2

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Article Information

Corresponding Author: Adam Cifu, MD, the University of Chicago, 5841 S Maryland Ave, MC 3051, Chicago, IL 60637 (adamcifu@uchicago.edu).

Published Online: July 21, 2022. doi:10.1001/jama.2022.12258

Conflict of Interest Disclosures: Dr Press reported grants from NHLBI Association (R01HL146644), grants from Agency for Healthcare Research and Quality (R01HS027804), and grants from American Lung Association outside the submitted work; he also receives consultant fees from Vizient Inc and Humana. No other disclosures were reported.

References
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Sobieraj  DM , Weeda  ER , Nguyen  E ,  et al.  Association of inhaled corticosteroids and long-acting β-agonists as controller and quick relief therapy with exacerbations and symptom control in persistent asthma: a systematic review and meta-analysis.   JAMA. 2018;319(14):1485-1496. doi:10.1001/jama.2018.2769PubMedGoogle ScholarCrossref
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Patel  MR , Press  VG , Gerald  LB ,  et al.  Improving the affordability of prescription medications for people with chronic respiratory disease. an official American Thoracic Society policy statement.   Am J Respir Crit Care Med. 2018;198(11):1367-1374. doi:10.1164/rccm.201810-1865STPubMedGoogle ScholarCrossref
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