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Coronavirus (COVID-19)

Association Between Vaccination and Acute Myocardial Infarction and Ischemic Stroke After COVID-19 Infection

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To identify the key insights or developments described in this article

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JAMA

Published Online: July 22, 2022

Research Letter

Article Information and Disclosures

Young-Eun Kim, PhD¹;

Kyungmin Huh, MD²;

Young-Joon Park, MD, MPH³;

Kyong Ran Peck, MD, PhD³;

Jaehun Jung, MD, PhD⁴

Author Affiliations

¹Big Data Department, National Health Insurance Service, Wonju, Korea
²Division of Infectious Diseases, Samsung Medical Center, Seoul, Korea
³Korea Disease Control and Prevention Agency, Cheongju, Korea
⁴Artificial Intelligence and Big-Data Convergence Center, Gachon University College of Medicine, Incheon, Korea

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Original Investigation

Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Patients With Influenza

Alexander E. Merkler, MD; Neal S. Parikh, MD, MS; Saad Mir, MD; Ajay Gupta, MD, MS; Hooman Kamel, MD, MS; Eaton Lin, MD; Joshua Lantos, MD; Edward J. Schenck, MD; Parag Goyal, MD; Samuel S. Bruce, MD, MA; Joshua Kahan, MBBS, PhD; Kelsey N. Lansdale, BA; Natalie M. LeMoss, BS; Santosh B. Murthy, MD, MPH; Philip E. Stieg, PhD, MD; Matthew E. Fink, MD; Costantino Iadecola, MD; Alan Z. Segal, MD; Marika Cusick, MS; Thomas R. Campion Jr, PhD, MS; Ivan Diaz, PhD; Cenai Zhang, MS; Babak B. Navi, MD, MS
Original Investigation

Stroke During the Convalescent Phase of Asymptomatic COVID-2019 in Men

Tian Ming Tu, MRCP; Christopher Ying Hao Seet, MRCP; Jasmine Shimin Koh, MRCP; Carol Huilian Tham, MRCP; Hui Jin Chiew, MRCP; Jasmyn Angon De Leon, MD; Christopher Yuan Kit Chua, MRCP; Andrew Che-Fai Hui, MRCP; Shaun Shi Yan Tan, MBChB; Shawn Sushilan Vasoo, MRCP; Benjamin Yong-Qiang Tan, MRCP; N. Thirugnanam Umapathi, MRCP; Paul Anantharajah Tambyah, MD; Leonard Leong Litt Yeo, MRCP, PhD
Research Letter

Myocardial Infarction, Stroke, and Pulmonary Embolism After BNT162b2 mRNA COVID-19 Vaccine

Marie Joelle Jabagi, PharmD, PhD; Jérémie Botton, PharmD, PhD; Marion Bertrand, MSc; Alain Weill, MD; Paddy Farrington, PhD; Mahmoud Zureik, MD, PhD; Rosemary Dray-Spira, MD, PhD
Comment & Response

Vaccination, Acute Myocardial Infarction, and Ischemic Stroke After COVID-19 Infection—Reply

Kyungmin Huh, MD; Young-Eun Kim, PhD; Jaehun Jung, MD, PhD
Comment & Response

Vaccination, Acute Myocardial Infarction, and Ischemic Stroke After COVID-19 Infection

Wei-Min Chu, MD, PhD; Chi-Yen Wang, MD; James Cheng-Chung Wei, MD, PhD

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Studies have suggested an increased incidence of acute myocardial infarction (AMI) and ischemic stroke after COVID-19 infection related to an increased risk of thrombosis.¹^,2 Vaccines against SARS-CoV-2 are effective against COVID-19 and its progression to severe disease.³ However, it is unclear if vaccines also prevent secondary complications. We examined the association between vaccination and AMI and ischemic stroke after COVID-19 infection.

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Article Information

Accepted for Publication: July 12, 2022.

Published Online: July 22, 2022. doi:10.1001/jama.2022.12992

Corresponding Author: Jaehun Jung, MD, PhD, Department of Preventive Medicine, Gachon University College of Medicine, 38-13, Dokjeom-ro 3, Incheon, 21565, Republic of Korea (eastside1st@gmail.com).

Author Contributions: Dr Jung had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Kim and Huh contributed equally to this work.

Concept and design: Kim, Huh, Jung.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Kim, Huh, Jung.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Kim, Huh, Jung.

Administrative, technical, or material support: Park, Peck, Jung.

Supervision: Jung.

Conflict of Interest Disclosures: Dr Huh reported grants from bioMérieux outside the submitted work. No other disclosures were reported.

Additional Contributions: We thank Do Tae Kang, MS; Soon-Ae Shin, PhD; Jong-Heon Park, MD, PhD; and Jai Yong Kim, MD, PhD, of the National Health Insurance Service, and Sang Won Lee, PhD, of the Korea Disease Control and Prevention Agency for the development and operation of the COVID-19 convergence big data platform. This study used data from the Korean National Health Insurance Service (NHIS-2022-1-363).

References

Xie Y , Xu E , Bowe B , Al-Aly Z . Long-term cardiovascular outcomes of COVID-19. Nat Med. 2022;28(3):583-590. doi:10.1038/s41591-022-01689-3 PubMed Google Scholar Crossref

Raman B , Bluemke DA , Lüscher TF , Neubauer S . Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus. Eur Heart J. 2022;43(11):1157-1172. doi:10.1093/eurheartj/ehac031 PubMed Google Scholar Crossref

Fiolet T , Kherabi Y , MacDonald CJ , Ghosn J , Peiffer-Smadja N . Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review. Clin Microbiol Infect. 2022;28(2):202-221. doi:10.1016/j.cmi.2021.10.005 PubMed Google Scholar Crossref

Thomas L , Li F , Pencina M . Using propensity score methods to create target populations in observational clinical research. JAMA. 2020;323(5):466-467. doi:10.1001/jama.2019.21558 PubMed Google Scholar Crossref

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