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Association Between Vaccination and Acute Myocardial Infarction and Ischemic Stroke After COVID-19 Infection

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Studies have suggested an increased incidence of acute myocardial infarction (AMI) and ischemic stroke after COVID-19 infection related to an increased risk of thrombosis.1,2 Vaccines against SARS-CoV-2 are effective against COVID-19 and its progression to severe disease.3 However, it is unclear if vaccines also prevent secondary complications. We examined the association between vaccination and AMI and ischemic stroke after COVID-19 infection.

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Article Information

Accepted for Publication: July 12, 2022.

Published Online: July 22, 2022. doi:10.1001/jama.2022.12992

Corresponding Author: Jaehun Jung, MD, PhD, Department of Preventive Medicine, Gachon University College of Medicine, 38-13, Dokjeom-ro 3, Incheon, 21565, Republic of Korea (eastside1st@gmail.com).

Author Contributions: Dr Jung had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Kim and Huh contributed equally to this work.

Concept and design: Kim, Huh, Jung.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Kim, Huh, Jung.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Kim, Huh, Jung.

Administrative, technical, or material support: Park, Peck, Jung.

Supervision: Jung.

Conflict of Interest Disclosures: Dr Huh reported grants from bioMérieux outside the submitted work. No other disclosures were reported.

Additional Contributions: We thank Do Tae Kang, MS; Soon-Ae Shin, PhD; Jong-Heon Park, MD, PhD; and Jai Yong Kim, MD, PhD, of the National Health Insurance Service, and Sang Won Lee, PhD, of the Korea Disease Control and Prevention Agency for the development and operation of the COVID-19 convergence big data platform. This study used data from the Korean National Health Insurance Service (NHIS-2022-1-363).

References
1.
Xie  Y , Xu  E , Bowe  B , Al-Aly  Z .  Long-term cardiovascular outcomes of COVID-19.   Nat Med. 2022;28(3):583-590. doi:10.1038/s41591-022-01689-3PubMedGoogle ScholarCrossref
2.
Raman  B , Bluemke  DA , Lüscher  TF , Neubauer  S .  Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus.   Eur Heart J. 2022;43(11):1157-1172. doi:10.1093/eurheartj/ehac031PubMedGoogle ScholarCrossref
3.
Fiolet  T , Kherabi  Y , MacDonald  CJ , Ghosn  J , Peiffer-Smadja  N .  Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review.   Clin Microbiol Infect. 2022;28(2):202-221. doi:10.1016/j.cmi.2021.10.005PubMedGoogle ScholarCrossref
4.
Thomas  L , Li  F , Pencina  M .  Using propensity score methods to create target populations in observational clinical research.   JAMA. 2020;323(5):466-467. doi:10.1001/jama.2019.21558PubMedGoogle ScholarCrossref
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