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Association Between Vaccination and Acute Myocardial Infarction and Ischemic Stroke After COVID-19 Infection

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Studies have suggested an increased incidence of acute myocardial infarction (AMI) and ischemic stroke after COVID-19 infection related to an increased risk of thrombosis.1,2 Vaccines against SARS-CoV-2 are effective against COVID-19 and its progression to severe disease.3 However, it is unclear if vaccines also prevent secondary complications. We examined the association between vaccination and AMI and ischemic stroke after COVID-19 infection.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: July 12, 2022.

Published Online: July 22, 2022. doi:10.1001/jama.2022.12992

Corresponding Author: Jaehun Jung, MD, PhD, Department of Preventive Medicine, Gachon University College of Medicine, 38-13, Dokjeom-ro 3, Incheon, 21565, Republic of Korea (eastside1st@gmail.com).

Author Contributions: Dr Jung had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Kim and Huh contributed equally to this work.

Concept and design: Kim, Huh, Jung.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Kim, Huh, Jung.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Kim, Huh, Jung.

Administrative, technical, or material support: Park, Peck, Jung.

Supervision: Jung.

Conflict of Interest Disclosures: Dr Huh reported grants from bioMérieux outside the submitted work. No other disclosures were reported.

Additional Contributions: We thank Do Tae Kang, MS; Soon-Ae Shin, PhD; Jong-Heon Park, MD, PhD; and Jai Yong Kim, MD, PhD, of the National Health Insurance Service, and Sang Won Lee, PhD, of the Korea Disease Control and Prevention Agency for the development and operation of the COVID-19 convergence big data platform. This study used data from the Korean National Health Insurance Service (NHIS-2022-1-363).

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 credit toward the CME [and Self-Assessment requirements] of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

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