Accepted for Publication: June 19, 2022.
Published: August 3, 2022. doi:10.1001/jamanetworkopen.2022.25331
Correction: This article was corrected on September 23, 2022, to fix an error in the Figure.
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Cosimi LA et al. JAMA Network Open.
Corresponding Authors: Lisa A. Cosimi, MD, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115 (lcosimi@bwh.harvard.edu); Deborah T. Hung, MD, PhD, Broad Institute, 415 Main St, Cambridge, MA 02142 (dhung@broadinstitute.org).
Author Contributions: Drs Cosimi and Hung had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Cosimi, Seitz, Connor, Hung.
Acquisition, analysis, or interpretation of data: Cosimi, Kelly, Esposito, Seitz, Turcinovic.
Drafting of the manuscript: Cosimi, Esposito, Connor.
Critical revision of the manuscript for important intellectual content: Cosimi, Kelly, Seitz, Turcinovic, Connor, Hung.
Statistical analysis: Cosimi.
Obtained funding: Hung.
Administrative, technical, or material support: Kelly, Esposito.
Supervision: Cosimi, Connor, Hung.
Conflict of Interest Disclosures: Dr Connor reported receiving personal fees from Cell Signaling Technologies, outside the submitted work. Dr Hung reported being a founder of, consultant to, equity holder in, and inventor of technology licensed to Sherlock Biosciences and serving on the scientific advisory board for Proof Diagnostics, outside the submitted work. No other disclosures were reported.
Funding/Support: Costs of this study were covered by operating funds of the Broad Institute of MIT and Harvard. Support for viral culture efforts was also provided by the Massachusetts Consortium on Pathogen Readiness (Dr Connor) and the China Evergrande Group to support viral culture efforts.
Role of the Funder/Sponsor: The Broad Institute’s Environmental Health and Safety Office informed individuals testing positive for COVID-19 of the opportunity to volunteer and consent for the study. The institute’s Procurement and Shipping Office mailed RATs to enrolled individuals.
Additional Contributions: We thank Jesse Souweine, MBA, Kelley Friedman, BS, Michael Nashed, BS, Stacy Gabriel, PhD, and Nicholas Fitzgerald, BS, from the Broad Insitute, Cambridge, Massachusetts, for logistical and organizational support. We thank Cole Sher-Jan, BS, at Boston University, Boston, Massachusetts, for help with rtPCR assays and sample logistics. None received compensation for this work outside of the their usual salaries.
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