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Rate of SARS-CoV-2 Reinfection During an Omicron Wave in Iceland

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

COVID-19 caused by SARS-CoV-2 was declared a global pandemic on March 11, 2020. Omicron, the currently dominant variant, is characterized by increased immune evasion, making reinfections more common.1,2 The relative protection of prior infection against reinfection with Omicron is 56% compared with 92% for the Delta variant.3 However, the population-level risk of reinfection with Omicron has not been described. The aim of this study was to estimate the proportion of persons who become reinfected with SARS-CoV-2 during the Omicron wave in Iceland.

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Article Information

Accepted for Publication: June 19, 2022.

Published: August 3, 2022. doi:10.1001/jamanetworkopen.2022.25320

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Eythorsson E et al. JAMA Network Open.

Corresponding Authors: Elias Eythorsson, MD, PhD, Landspitali–The National University Hospital of Iceland, Skaftahlid 24, 105 Reykjavik, Iceland (elias.eythorsson@gmail.com); Runolfur Palsson, MD, Landspitali–The National University Hospital of Iceland, Skaftahlid 24, 105 Reykjavik, Iceland (runolfur@landspitali.is).

Author Contributions: Drs Eythorsson and Palsson had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Eythorsson, Sigurdsson, Palsson.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Eythorsson, Sigurdsson.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Eythorsson.

Obtained funding: Eythorsson, Palsson.

Administrative, technical, or material support: Ingvarsson, Sigurdsson, Palsson.

Supervision: Sigurdsson, Palsson.

Conflict of Interest Disclosures: None reported.

Funding/Support: This work was supported by the Landspitali University Hospital Research Fund (grant A-2021-051). Neither the authors nor their institutions received payment or services from a third party for any aspect of the submitted work.

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References
1.
Eggink  D , Andeweg  SP , Vennema  H ,  et al.  Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022.   Euro Surveill. 2022;27(4):2101196. doi:10.2807/1560-7917.ES.2022.27.4.2101196PubMedGoogle ScholarCrossref
2.
Pulliam  JRC , van Schalkwyk  C , Govender  N ,  et al.  Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa.   Science. 2022;376(6593):eabn4947. doi:10.1126/science.abn4947PubMedGoogle ScholarCrossref
3.
Altarawneh  HN , Chemaitelly  H , Hasan  MR ,  et al.  Protection against the Omicron variant from previous SARS-CoV-2 infection.   N Engl J Med. 2022;386(13):1288-1290. doi:10.1056/NEJMc2200133PubMedGoogle ScholarCrossref
4.
Harrell  FE  Jr .  Regression Modeling Strategies. 2nd ed. Springer International Publishing; 2016.
5.
Iceland Directorate of Health. COVID-19 vaccinations in Iceland: statistics. 2022. Accessed March 11, 2022. https://www.covid.is/statistical-information-on-vaccination
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