Accepted for Publication: July 27, 2022.
Published Online: August 5, 2022. doi:10.1001/jama.2022.14092
Corresponding Author: Marian Rewers, MD, PhD, Barbara Davis Center for Diabetes, University of Colorado School of Medicine, 1775 Aurora Ct, B-140, Aurora, CO 80045 (email@example.com).
Author Contributions: Dr Rewers had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Rewers, Bonifacio, Geno Rasmussen, Ziegler.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Rewers, Geno Rasmussen, Ziegler.
Critical revision of the manuscript for important intellectual content: Bonifacio, Ewald, Geno Rasmussen, Jia, Pyle, Ziegler.
Statistical analysis: Geno Rasmussen, Pyle, Ziegler.
Obtained funding: Rewers, Ziegler.
Administrative, technical, or material support: Rewers, Ewald, Geno Rasmussen, Jia, Ziegler.
Supervision: Rewers, Bonifacio.
Other - Measurement of antibodies: Bonifacio.
Conflict of Interest Disclosures: None reported.
Funding/Support: The ASK Study (3-SRA-2018-564-M-N) is funded by JDRF International, The Leona M. and Harry B. Helmsley Charitable Trust, and Janssen Research and Development LLC. Additional support came from the Courtenay C. and Lucy Patten Davis Foundation and the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (University of Colorado Diabetes Research Center grant DK116073). The Fr1da Study was supported by grants from LifeScience-Stiftung (HMGU 2014.01 and HMGU 2016.01), Juvenile Diabetes Research Foundation International (1-SRA-2014-310-M-R, 3-SRA-2015-72-M-R, 3-SRA-2019-718-Q-R), the Bavarian State Ministry of Health and Care (Gesund.Leben.Bayern, LP00228), The Leona M. and Harry B. Helmsley Charitable Trust (G-1911-03274), and the German Center for Diabetes Research (DZD e.V.). This work was supported by a grant from the German Federal Ministry of Education and Research (FKZ01KX1818).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: The members of the ASK Study Group can be found at https://www.askhealth.org/about-us and the Fr1da Study Group at https://www.typ1diabetes-frueherkennung.de/informationen-fuer-aerzte/the-fr1da-study-group.html.
Additional Contributions: We thank Brigitte I. Frohnert, MD, PhD, Hanan Shorrosh, BS, Kimber Simmons, MD, Marisa Stahl, MD, Andrea K. Steck, MD, and Liping Yu, MD (Barbara Davis Center University of Colorado, Aurora), Peter Achenbach, MD, Marlon Scholz, CTA, and Franziska Voss, MS (Institute of Diabetes Research Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany), and Esra Karapinar, MD (Technical University Munich, School of Medicine, Forschergruppe Diabetes at Klinikum rechts der Isar, Munich, Germany), for their contributions and critical review of the manuscript as well as other members of the ASK Study Group and Fr1da Study Group. They were supported by the ASK and Fr1da studies.
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