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Update on the Monkeypox Outbreak

To identify the key insights or developments described in this article
1 Credit CME

The current monkeypox outbreak was declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO) director-general on July 23, 2022. As of August 9, 2022, nearly 32 000 confirmed cases of monkeypox had been reported across 82 nonendemic countries.1 Given the rapid pace with which cases are being diagnosed, a coordinated international response is essential.2

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Article Information

Corresponding Author: Carlos del Rio, MD, Emory University School of Medicine, 49 Jesse Hill Jr Dr SE, Atlanta, GA 30303 (cdelrio@emory.edu).

Published Online: August 11, 2022. doi:10.1001/jama.2022.14857

Conflict of Interest Disclosures: Dr del Rio reported receipt of grants from the National Institutes of Health/National Institute of Allergy and Infectious Diseases to his institution. No other disclosures were reported.

References
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CDC. 2022 U.S. monkeypox outbreak. Accessed August 9, 2022. https://www.cdc.gov/poxvirus/monkeypox/response/2022/index.html
2.
Nuzzo  JB , Borio  LL , Gostin  LO .  The WHO declaration of monkeypox as a global health emergency.   JAMA. Published online July 27, 2022. doi:10.1001/jama.2022.12513PubMedGoogle ScholarCrossref
3.
Guarner  J , Del Rio  C , Malani  PN .  Monkeypox in 2022: what clinicians need to know.   JAMA. 2022;328(2):139-140. doi:10.1001/jama.2022.10802 PubMedGoogle ScholarCrossref
4.
Lapa  D , Carletti  F , Mazzotta  V ,  et al.  Monkeypox virus isolation from a semen sample collected in the early phase of infection in a patient with prolonged seminal viral shedding.   Lancet Inf Dis. Published online August 2, 2022. doi:10.1016/S1473-3099(22)00513-8 Google ScholarCrossref
5.
CDC. Technical Report: Multi-National Monkeypox Outbreak, United States, 2022. Updated July 28, 2022. Accessed August 2, 2022. https://www.cdc.gov/poxvirus/monkeypox/clinicians/technical-report.html
6.
Thornhill  JP , Barkati  S , Walmsley  S ,  et al.  Monkeypox virus infection in humans across 16 countries: April-June 2022.   N Engl J Med. Published online July 21, 2022. doi:10.1056/NEJMoa2207323 PubMedGoogle ScholarCrossref
7.
Soucheray  S . Non-endemic countries record first monkeypox deaths. CIDRAP News. August 1, 2022. https://www.cidrap.umn.edu/news-perspective/2022/08/non-endemic-countries-record-first-monkeypox-deaths
8.
CDC. Monkeypox and smallpox vaccine guidance. Accessed August 5, 2022. https://www.cdc.gov/poxvirus/monkeypox/clinicians/smallpox-vaccine.html
9.
Nalca  A , Zumbrun  EE .  ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile.   Drug Des Devel Ther. 2010;4:71-79. doi:10.2147/DDDT.S3687 PubMedGoogle ScholarCrossref
10.
Frey  SE , Wald  A , Edupuganti  S ,  et al.  Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects.   Vaccine. 2015;33(39):5225-5234. doi:10.1016/j.vaccine.2015.06.075 PubMedGoogle ScholarCrossref
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