Corresponding Authors: Wilbur A. Lam, MD, PhD, Emory Children’s Center, 2015 Uppergate Dr NE, Room 448, Atlanta, GA 30322 (email@example.com); Greg S. Martin, MD, MSc, Emory University School of Medicine, 49 Jesse Hill Jr Dr SE, Atlanta, GA 30303 (firstname.lastname@example.org).
Accepted for Publication: August 9, 2022.
Published Online: August 26, 2022. doi:10.1001/jama.2022.14877
Author Contributions: Drs Waggoner and Lam had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Waggoner and Vos and Ms Tyburski contributed equally to this work.
Concept and design: Waggoner, Vos, Tyburski, Nguyen, Sullivan, Jerris, Levy, Farmer, Peagler, Wood, Heetderks, Li, Roth, Barcus, Stenzel, Lam.
Acquisition, analysis, or interpretation of data: Waggoner, Vos, Tyburski, Nguyen, Ingersoll, Miller, Griffiths, Stone, Benoit, Benedit, Seitter, Jerris, Levy, Kraft, Farmer, Wood, Westbrook, Morris, Sathian, Roth, Stenzel, Martin, Lam.
Drafting of the manuscript: Waggoner, Vos, Tyburski, Nguyen, Sullivan, Benoit, Benedit, Levy, Farmer, Peagler, Wood, Stenzel, Lam.
Critical revision of the manuscript for important intellectual content: Waggoner, Vos, Ingersoll, Miller, Griffiths, Stone, Benedit, Seitter, Jerris, Levy, Kraft, Westbrook, Morris, Sathian, Heetderks, Li, Roth, Barcus, Stenzel, Martin, Lam.
Statistical analysis: Waggoner, Tyburski, Benedit, Wood, Westbrook, Barcus, Lam.
Obtained funding: Heetderks, Martin, Lam.
Administrative, technical, or material support: Waggoner, Vos, Tyburski, Ingersoll, Miller, Sullivan, Griffiths, Stone, Benoit, Benedit, Seitter, Levy, Kraft, Wood, Sathian, Roth, Barcus, Stenzel, Martin, Lam.
Supervision: Waggoner, Vos, Sullivan, Griffiths, Levy, Kraft, Sathian, Stenzel, Lam.
Conflict of Interest Disclosures: Dr Waggoner reported receiving grants from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) during the conduct of the study. Ms Tyburski reported receiving grants from the National Institutes of Health (NIH; U54 center grant) during the conduct of the study. Dr Levy reported receiving grants from the NIH (1R03TR004022-01) outside the submitted work. Dr Kraft reported serving on the advisory boards of Rebiotix/Ferring and Seres Therapeutic outside the submitted work. Dr Morris reported receiving grants from the NIH (Rapid Acceleration of Diagnostics [RADx] grant funding) during the conduct of the study and having a patent for therapies for the treatment of coronaviruses pending (Emory patent-pending). Dr Martin reported receiving grants from the NIH (to Emory University) during the conduct of the study. Dr Lam reported receiving grants from the NIBIB during the conduct of the study. No other disclosures were reported.
Funding/Support: This work was supported by the NIBIB at the NIH under awards U54 EB027690-03S1 and U54 EB027690-03S2 and the National Center for Advancing Translational Sciences of the NIH under award UL1TR002378.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Additional Contributions: We thank the participants and their families for participation in this study. We acknowledge the contributions of Children’s Healthcare of Atlanta research coordinators Misty McGhee, AS, LPN; Lauren Robinsons, MS; and Rashad Wood, BS, on this project. These individuals did not receive financial compensation specifically for participation on this project. This study was a collaboration between Emory University, Children’s Healthcare of Atlanta, the RADx initiative of the NIH’s NIBIB, and the Food and Drug Administration. We acknowledge the helpful comments and feedback from team members affiliated with each of these entities during all phases of the study. The Children’s Clinical and Translational Discovery Core is supported by Children’s Healthcare of Atlanta and Emory University.
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