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Evaluation of Risk Factors for Postbooster Omicron COVID-19 Deaths in England

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

With the emergence of the Omicron variant, it has become critical to identify risk factors associated with COVID-19 death in individuals who have completed primary vaccination and received a messenger RNA (mRNA) booster dose. Existing evidence is based on people who have received 1 or 2 doses of a COVID-19 vaccine and were infected by the Alpha or Delta variant.13 Understanding which groups are at increased risk of COVID-19 death after receiving a booster is crucial for the prioritization of further booster doses and access to COVID-19 therapeutics.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: August 8, 2022.

Published: September 8, 2022. doi:10.1001/jamanetworkopen.2022.33446

Correction: This article was corrected on September 29, 2022, to fix a row label in the Table (Sickle cell and severe combined immunodeficiency syndrome). Severe combined immunodeficiency syndrome has been removed and the data are now presented correctly.

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Nafilyan V et al. JAMA Network Open.

Corresponding Author: Isobel L.Ward, PhD, Office for National Statistics, Government Buildings, Cardiff Road, Newport, NP10 8XG, United Kingdom (isobel.ward@ons.gov.uk).

Author Contributions: Drs Nafilyan and Ward had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Nafilyan and Ward contributed equally.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: Nafilyan, Ward, Roberston.

Drafting of the manuscript: Nafilyan, Ward.

Critical revision of the manuscript for important intellectual content: Ward, Roberston, Sheikh.

Statistical analysis: Nafilyan, Ward.

Obtained funding: Nafilyan, Sheikh.

Administrative, technical, or material support: Nafilyan, Ward, Sheikh.

Supervision: Nafilyan, Roberston.

Conflict of Interest Disclosures: Dr Roberston reported service as a member of UK and Scottish government advisory committees, including the Scientific Pandemic Influenza Group on Modeling, Scottish Government Scientific Advisory Committee, and Medicines and Healthcare products Regulatory Agency COVID vaccine benefit and risk expert working group. Dr Sheikh reported service in uncompensated advisory roles on COVID-19 to UK and Scottish Governments and AstraZeneca. No other disclosures were reported.

Funding/Support: This research was funded by the National Core Studies–Immunity and received additional support from National Core Studies–Data and Connectivity, Health Data Research UK, and the Medical Research Council.

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Meeting Presentation: This work has been accepted for a Rapid Fire talk at the Royal Statistical Society International Conference; September 12-15, 2022; Aberdeen, Scotland.

References
1.
Hippisley-Cox  J , Coupland  CA , Mehta  N ,  et al.  Risk prediction of COVID-19 related death and hospital admission in adults after COVID-19 vaccination: national prospective cohort study.   BMJ. 2021;374:n2244. doi:10.1136/bmj.n2244Google ScholarCrossref
2.
Grange  Z , Buelo  A , Sullivan  C , Moore  E , Agrawal  U , Boukhari  K , McLaughlan  I , Stockton  D , McCowan  C , Robertson  C , Sheikh  A , Murray  JLK .  Characteristics and risk of COVID-19–related death in fully vaccinated people in Scotland.   Lancet. 2021;398(10313):1799-1800. doi:10.1016/S0140-6736(21)02316-3Google ScholarCrossref
3.
Agrawal  U , Katikireddi  SV , McCowan  C ,  et al.  COVID-19 hospital admissions and deaths after BNT162b2 and ChAdOx1 nCoV-19 vaccinations in 2.57 million people in Scotland (EAVE II): a prospective cohort study.   Lancet Respir Med. 2021.;9(12):1439-1449. doi:10.1016/S2213-2600(21)00380-5Google ScholarCrossref
4.
Bosworth  ML , Ahmed  T , Larsen  T ,  et al.  Ethnic differences in COVID-19 mortality in the second and third waves of the pandemic in England during the vaccine roll-out: a retrospective, population-based cohort study.   medRxiv. Preprint posted online February 15, 2022. doi:10.1101/2022.02.14.22270940 Google Scholar
5.
Emanuel  EJ , Persad  G , Upshur  R ,  et al.  Fair allocation of scarce medical resources in the time of COVID-19.   N Engl J Med. 2020:382(21):2049-2055. doi:10.1056/NEJMsb2005114Google ScholarCrossref
6.
Reis  G , Silva  EASM , Silva  DCM , Thabane  L ,  et al.  Effect of early treatment with ivermectin among patients with COVID-19.   N Engl J Med. 2022;386(18):1721-1731. doi:10.1056/NEJMoa2115869Google ScholarCrossref

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