Mass vaccination campaigns have been conducted worldwide to control the COVID-19 pandemic. Despite reassuring safety profiles in clinical trials, vaccine hesitancy remains high among individuals of reproductive age, partially because of fertility concerns.1 Recent studies have shown that messenger RNA and viral-vector SARS-CoV-2 vaccinations do not impair sperm parameters among participants.2- 5 However, the effects of inactivated SARS-CoV-2 vaccines—the most widely used vaccine type in mainland China—on semen quality have not been assessed. We evaluated changes in semen quality before and after inactivated SARS-CoV-2 vaccination among men in China.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: July 22, 2022.
Published: September 8, 2022. doi:10.1001/jamanetworkopen.2022.30631
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Huang J et al. JAMA Network Open.
Corresponding Authors: Jiaying Lin, MD, Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd, Huangpu District, Shanghai 200011, China (email@example.com); or Qiongfang Wu, MD, Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Nanchang University School of Medicine, 318 Bayi Ave, Donghu District, Nanchang 330006, China (firstname.lastname@example.org).
Author Contributions: Drs Huang and Wu had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Dr Huang, Mr Xia, and Dr Tian contributed equally to this work and are considered co–first authors.
Concept and design: Huang, Xia, Fang, Wu.
Acquisition, analysis, or interpretation of data: Huang, Xia, Tian, Xu, Lin, Wu.
Drafting of the manuscript: Huang, Lin.
Critical revision of the manuscript for important intellectual content: Huang, Xia, Tian, Xu, Fang, Wu.
Statistical analysis: Huang, Xia.
Obtained funding: Tian, Wu.
Administrative, technical, or material support: Xu, Fang, Lin.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was funded by grant 81960288 from the National Natural Science Foundation of China, grant 20203BBGL73159 from the Key Research and Development Program of Jiangxi Province, and grant 20211008 from the Science and Technology Project of Jiangxi Provincial Health Commission.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank the patients for their participation in this study and their cooperation during follow-up. We also thank the staff members at the Center for Reproductive Medicine of Jiangxi Maternal and Child Health Hospital who contributed to database construction and quality management.
Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:
It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.
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