Accepted for Publication: August 25, 2022.
Published Online: September 20, 2022. doi:10.1001/jamaneurol.2022.3491
Corresponding Author: Avindra Nath, MD, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bldg 10, Room 7C-103, Bethesda, MD 20892 (firstname.lastname@example.org).
Author Contributions: Dr Nath had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Billioux, Mbaya, Nath.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Billioux, Mbaya, Nath.
Critical revision of the manuscript for important intellectual content: All authors.
Administrative, technical, or material support: All authors.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported in part by the National Institutes of Health (Drs Billioux, Mbaya, and Nath) and the Center for Disease Control and Prevention (Dr Sejvar).
Role of the Funder/Sponsor: These organizations have approved the manuscript for publication. The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation or review of the manuscript; and decision to submit the manuscript for publication. The funding sources approved the manuscript for publication.
Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
AR . Smallpox. Kothari Book Depot; 1972.
RD . Smallpox and vaccinia: the pathologic histology. Arch Pathol (Chic)
. 1930;10:241-291.Google Scholar
A , Fuertes
I , Camprubí-Ferrer
et al; Hospital Clinic de Barcelona Monkeypox Study Group. Frequent detection of monkeypox virus DNA in saliva, semen, and other clinical samples from 12 patients, Barcelona, Spain, May to June 2022. Euro Surveill
. 2022;27(28). doi:10.2807/1560-7917.ES.2022.27.28.2200503PubMedGoogle ScholarCrossref
N , Byrne
R , Bracchi
et al. Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London, UK: an observational analysis. Lancet Infect Dis
. 2022;22(9):1321-1328. doi:10.1016/S1473-3099(22)00411-XPubMedGoogle ScholarCrossref
ER , Bonwitt
J , Hughes
et al. Clinical and epidemiological findings from enhanced monkeypox surveillance in Tshuapa Province, Democratic Republic of the Congo during 2011-2015. J Infect Dis
. 2021;223(11):1870-1878. doi:10.1093/infdis/jiab133PubMedGoogle ScholarCrossref
H , Gould
S , Hine
et al; NHS England High Consequence Infectious Diseases (Airborne) Network. Clinical features and management of human monkeypox: a retrospective observational study in the UK. Lancet Infect Dis
. 2022;22(8):1153-1162. doi:10.1016/S1473-3099(22)00228-6PubMedGoogle ScholarCrossref
J , Snoeck
R , Schols
D , Balzarini
J , De Clercq
E . Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG). Virology
. 1990;179(1):41-50. doi:10.1016/0042-6822(90)90271-RPubMedGoogle ScholarCrossref
E , Holý
A , Rosenberg
I . Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo. Antimicrob Agents Chemother
. 1989;33(2):185-191. doi:10.1128/AAC.33.2.185PubMedGoogle ScholarCrossref
N . Monkeypox virus. In: Malik
YS , Singh
RK , Dhama
K , eds. Animal-Origin Viral Zoonoses Livestock Diseases and Management
. Springer; 2020:39-68. doi:10.1007/978-981-15-2651-0_2
AK , Petersen
BW , Whitehill
et al. Use of JYNNEOS (smallpox and monkeypox vaccine, live, nonreplicating) for preexposure vaccination of persons at risk for occupational exposure to orthopoxviruses: recommendations of the advisory committee on immunization practices—US, 2022. MMWR Morb Mortal Wkly Rep
. 2022;71(22):734-742. doi:10.15585/mmwr.mm7122e1PubMedGoogle ScholarCrossref