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Neurogenic Unilateral Leg Edema

To identify the key insights or developments described in this article
1 Credit CME

Unilateral leg edema is almost always caused by a disease process that obstructs the venous or lymphatic drainage in the leg or pelvis but can also occur in chronic regional pain syndrome (CRPS).1 We report unilateral leg edema that was a consequence of CRPS induced by an S1 radiculopathy (type 2 CRPS). We show that the etiology of the edema was neurogenic because a posterior tibial nerve block abolished the edema distal to the block.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Howard Feit, MD, PhD, Henry Ford Hospital, 6358 Timberwood S, West Bloomfield, MI 48322 (feit.howard@gmail.com).

Published Online: September 26, 2022. doi:10.1001/jamaneurol.2022.2933

Conflict of Interest Disclosures: None reported.

References
1.
Harden  NR , Bruehl  S , Perez  RSGM ,  et al.  Validation of proposed diagnostic criteria (the “Budapest criteria”) for complex regional pain syndrome.   Pain. 2010;150(2):268-274. doi:10.1016/j.pain.2010.04.030PubMedGoogle ScholarCrossref
2.
Howarth  D , Burstal  R , Hayes  C , Lan  L , Lantry  G .  Autonomic regulation of lymphatic flow in the lower extremity demonstrated on lymphoscintigraphy in patients with reflex sympathetic dystrophy.   Clin Nucl Med. 1999;24(6):383-387. doi:10.1097/00003072-199906000-00001PubMedGoogle ScholarCrossref
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