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Odds of Hospitalization for COVID-19 After 3 vs 2 Doses of mRNA COVID-19 Vaccine by Time Since Booster Dose

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

Vaccination with a booster dose of COVID-19 mRNA vaccine has been associated with decreased risk of developing severe COVID-19 compared with no vaccination.1,2 However, among individuals already fully vaccinated with the primary series of an mRNA vaccine, less is known about how much protection is added by a booster and how long that protection lasts. We assessed the association between COVID-19 mRNA booster immunization compared with vaccination with the primary mRNA vaccination series alone and the odds of hospitalization for COVID-19.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: September 12, 2022.

Published Online: September 23, 2022. doi:10.1001/jama.2022.17811

Corresponding Author: Jessica P. Ridgway, MD, Department of Medicine, University of Chicago, 5841 S Maryland Ave, MC 5065, Chicago, IL 60637 (Jessica.ridgway@uchospitals.edu).

Author Contributions: Dr Robicsek had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Ridgway, Tideman, Wright, Diaz, Robicsek.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Ridgway, Tideman, Wright, Robicsek.

Critical revision of the manuscript for important intellectual content: Tideman, French, Wright, Parsons, Diaz, Robicsek.

Statistical analysis: Tideman, French, Wright, Robicsek.

Obtained funding: Robicsek.

Administrative, technical, or material support: Tideman, Parsons, Diaz, Robicsek.

Supervision: Parsons, Robicsek.

Conflict of Interest Disclosures: Dr Ridgway reported receiving personal fees from Gilead Sciences. Dr Diaz reported receiving grants from Gilead, Roche, Regeneron, Edesa Biotech Inc, Boehringer Ingelheim, NeuroBo Pharmaceuticals Inc, and the National Institutes of Health and serving as a scientific board member for Safeology. No other disclosures were reported.

References
1.
Accorsi  EK , Britton  A , Shang  N ,  et al.  Effectiveness of homologous and heterologous Covid-19 boosters against Omicron.   N Engl J Med. 2022;386(25):2433-2435. doi:10.1056/NEJMc2203165PubMedGoogle ScholarCrossref
2.
Andrews  N , Stowe  J , Kirsebom  F ,  et al.  Effectiveness of COVID-19 booster vaccines against COVID-19–related symptoms, hospitalization and death in England.   Nat Med. 2022;28(4):831-837. doi:10.1038/s41591-022-01699-1PubMedGoogle ScholarCrossref
3.
Wright  BJ , Tideman  S , Diaz  GA , French  T , Parsons  GT , Robicsek  A .  Comparative vaccine effectiveness against severe COVID-19 over time in US hospital administrative data: a case-control study.   Lancet Respir Med. 2022;10(6):557-565. doi:10.1016/S2213-2600(22)00042-XPubMedGoogle ScholarCrossref
4.
Tartof  SY , Slezak  JM , Puzniak  L ,  et al.  Durability of BNT162b2 vaccine against hospital and emergency department admissions due to the Omicron and Delta variants in a large health system in the USA: a test-negative case-control study.   Lancet Respir Med. 2022;10(7):689-699. doi:10.1016/S2213-2600(22)00101-1PubMedGoogle ScholarCrossref
5.
Butt  AA , Talisa  VB , Shaikh  OS , Omer  SB , Mayr  FB .  Relative vaccine effectiveness of a SARS-CoV-2 mRNA vaccine booster dose against the Omicron variant.   Clin Infect Dis. 2022;ciac328. doi:10.1093/cid/ciac328PubMedGoogle ScholarCrossref
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