Corresponding Author: Meera Viswanathan, PhD, RTI International, 3040 E Cornwallis Rd, Research Triangle Park, NC 27709 (email@example.com).
Accepted for Publication: August 25, 2022.
Author Contributions: Dr Viswanathan had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Viswanathan, Kahwati.
Acquisition, analysis, or interpretation of data: Viswanathan, Wallace, Cook Middleton, Kennedy, McKeeman, Hudson, Rains, Vander Schaaf, Kahwati.
Drafting of the manuscript: Viswanathan, Kennedy, Rains.
Critical revision of the manuscript for important intellectual content: Viswanathan, Wallace, Cook Middleton, Kennedy, McKeeman, Hudson, Rains, Vander Schaaf, Kahwati.
Statistical analysis: Viswanathan, Wallace, Kahwati.
Obtained funding: Viswanathan, Kahwati.
Administrative, technical, or material support: Viswanathan, Kennedy, Rains.
Conflict of Interest Disclosures: Dr Vander Schaaf reported that she is a Fellow of the American Academy of Pediatrics and member of American Academy of Pediatrics CATCH Committee. No other disclosures were reported.
Funding/Support: This study was funded under contract HHSA-290-2015-00011-I, Task Order 15, and Contract 75Q80120D00007, Task Order 05, from the Agency for Healthcare Research and Quality (AHRQ), US Department of Health and Human Services (HHS), under a contract to support the US Preventive Services Task Force (USPSTF).
Role of the Funder/Sponsor: Investigators worked with USPSTF members and AHRQ staff to develop the scope, analytic framework, and key questions for this review. AHRQ had no role in study selection, quality assessment, or synthesis. AHRQ staff provided project oversight, reviewed the report to ensure that the analysis met methodological standards, and distributed the draft for peer review. Otherwise, AHRQ had no role in the conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript findings. The opinions expressed in this document are those of the authors and do not represent the official position of AHRQ or HHS.
Additional Contributions: We acknowledge the following individuals for their contributions to this project: AHRQ staff Iris Mabry-Hernandez, MD, MPH, and Tracy Wolf, MD, MPH; current and former members of the USPSTF who contributed to topic deliberations; and RTI International–University of North Carolina Evidence-based Practice Center staff Christiane Voisin, MSLS, Candi Wines, MPH, Nila A. Sathe, MA, MLIS, Carol Woodell, BSPH, Sharon Barrell, MA, Staci Rachman, BA, Sarah Barringer, Michelle Bogus, Teyonna Downing, and Loraine Monroe. USPSTF members, peer reviewers, and federal partner reviewers did not receive financial compensation for their contributions.
Additional Information: A draft version of the full evidence report underwent external peer review from 4 content experts (Gregory Simon, MD, MPH, University of Washington; Joan Asarnow, PhD, University of California, Los Angeles; Natalie Cort, PhD, William James College; and Raquel Halfond, PhD, American Psychological Association) and 1 federal partner reviewer (Erin Abramsohn, DrPH, Centers for Disease Control and Prevention). Comments from reviewers were presented to the USPSTF during its deliberation of the evidence and were considered by the authors in preparing the final evidence review.
Editorial Disclaimer: This evidence report is presented as a document in support of the accompanying USPSTF recommendation statement. It did not undergo additional peer review after submission to JAMA.
US Department of Commerce. 2020 National Survey of Children’s Health: Topical Frequencies. US Census Bureau; 2021.
K , Höfler
M , Gloster
et al. The structure of common mental disorders: a replication study in a community sample of adolescents and young adults. Int J Methods Psychiatr Res
. 2009;18(4):204-220. doi:10.1002/mpr.293PubMedGoogle ScholarCrossref
M , Wallace
I , Cook Middleton
et al. Screening for Depression, Anxiety, and Suicide Risk in Children and Adolescents: An Evidence Review for the US Preventive Services Task Force. Evidence Synthesis No. 221. Agency for Healthcare Research and Quality; 2022. AHRQ publication 22-05293-EF-1.
J , Higgins
J , Altman
DG ; Cochrane Statistical Methods Group. Analysing data and undertaking meta-analyses. In: Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M, Welch V, eds. Cochrane Handbook for Systematic Reviews of Interventions
. Cochrane. Published 2022. Accessed August 31, 2022. https://training.cochrane.org/handbook
M , Wallace
IF , Cook Middleton
et al. Screening for depression and suicide risk in children and adolescents: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA
. Published online October 11, 2022. doi:10.1001/jama.2022.16310Google Scholar
J , Hernández-Martínez
C , Cosi
S , Domènech
E . Examination of a cutoff score for the Screen for Child Anxiety Related Emotional Disorders (SCARED) in a non-clinical Spanish population. J Anxiety Disord
. 2012;26(8):785-791. doi:10.1016/j.janxdis.2012.07.008PubMedGoogle ScholarCrossref
JG , Harris
ES , Spitzer
RL , Williams
JBW . The patient health questionnaire for adolescents: validation of an instrument for the assessment of mental disorders among adolescent primary care patients. J Adolesc Health
. 2002;30(3):196-204. doi:10.1016/S1054-139X(01)00333-0PubMedGoogle ScholarCrossref
P , Merckelbach
H , Kindt
et al. The utility of Screen for Child Anxiety Related Emotional Disorders (SCARED) as a tool for identifying children at high risk for prevalent anxiety disorders. Anxiety Stress Coping
. 2001;14(3):265-283. doi:10.1080/10615800108248357Google ScholarCrossref
K , Kaltiala-Heino
R , Rantanen
P , Tuomisto
MT , Marttunen
M . Screening social phobia in adolescents from general population: the validity of the Social Phobia Inventory (SPIN) against a clinical interview. Eur Psychiatry
. 2007;22(4):244-251. doi:10.1016/j.eurpsy.2006.12.002PubMedGoogle ScholarCrossref
SI , Kikuta
K , Sakai
M , Mitamura
T , Motomura
N , Hudson
JL . A randomized controlled trial of a bidirectional cultural adaptation of cognitive behavior therapy for children and adolescents with anxiety disorders. Behav Res Ther
. 2019;120:103432. doi:10.1016/j.brat.2019.103432PubMedGoogle ScholarCrossref
JH , Lebowitz
ER , Jakubovski
E , Coughlin
CG , Silverman
WK , Bloch
MH . Monotherapy insufficient in severe anxiety? predictors and moderators in the child/adolescent anxiety multimodal study. J Clin Child Adolesc Psychol
. 2018;47(2):266-281. doi:10.1080/15374416.2017.1371028PubMedGoogle ScholarCrossref
SN , Peris
TS , Almirall
et al. Predictors and moderators of treatment response in childhood anxiety disorders: results from the CAMS trial. J Consult Clin Psychol
. 2014;82(2):212-224. doi:10.1037/a0035458PubMedGoogle ScholarCrossref
AT , Becker
EM , Ginsburg
et al. Anxiety disorders in Caucasian and African American children: a comparison of clinical characteristics, treatment process variables, and treatment outcomes. Child Psychiatry Hum Dev
. 2015;46(5):643-655. doi:10.1007/s10578-014-0507-xPubMedGoogle ScholarCrossref
GS , Kendall
PC , Sakolsky
et al. Remission after acute treatment in children and adolescents with anxiety disorders: findings from the CAMS. J Consult Clin Psychol
. 2011;79(6):806-813. doi:10.1037/a0025933PubMedGoogle ScholarCrossref
JR , Prakash
A , Zhang
et al. A randomized, placebo-controlled study of duloxetine for the treatment of children and adolescents with generalized anxiety disorder. J Am Acad Child Adolesc Psychiatry
. 2015;54(4):283-293. doi:10.1016/j.jaac.2015.01.008PubMedGoogle ScholarCrossref
S , Stefini
A , Kronmüller
et al. Cognitive-behavioral and psychodynamic therapy in adolescents with social anxiety disorder: a multicenter randomized controlled trial. Psychother Psychosom
. 2018;87(4):223-233. doi:10.1159/000488990PubMedGoogle ScholarCrossref
S , Hougaard
E , McLellan
LF , Thastum
M . A randomized controlled trial examining the efficacy of an internet-based cognitive behavioral therapy program for adolescents with anxiety disorders. PLoS One
. 2019;14(9):e0222485. doi:10.1371/journal.pone.0222485PubMedGoogle ScholarCrossref
D , Furr
JM , Sanchez
et al. Intensive group behavioral treatment (IGBT) for children with selective mutism: a preliminary randomized clinical trial. J Consult Clin Psychol
. 2019;87(8):720-733. doi:10.1037/ccp0000422PubMedGoogle ScholarCrossref
J , Heinrichs
N , Schmidtendorf
S , Nitschke
K , Tuschen-Caffier
B . Experience versus report: where are changes seen after exposure-based cognitive-behavioral therapy? a randomized controlled group treatment of childhood social anxiety disorder. Child Psychiatry Hum Dev
. 2020;51(3):427-441. doi:10.1007/s10578-019-00954-wPubMedGoogle ScholarCrossref
DS , Walkup
JT , Labellarte
et al; Research Units on Pediatric Psychopharmacology Anxiety Study Group. Fluvoxamine for the treatment of anxiety disorders in children and adolescents. N Engl J Med
. 2001;344(17):1279-1285. doi:10.1056/NEJM200104263441703PubMedGoogle ScholarCrossref
JT , Labellarte
MJ , Riddle
et al; Research Units on Pediatric Psychopharmacology Anxiety Study Group. Searching for moderators and mediators of pharmacological treatment effects in children and adolescents with anxiety disorders. J Am Acad Child Adolesc Psychiatry
. 2003;42(1):13-21. doi:10.1097/00004583-200301000-00006PubMedGoogle ScholarCrossref
SP , DosReis
S , Walkup
JT , Riddle
MA . Activation adverse events induced by the selective serotonin reuptake inhibitor fluvoxamine in children and adolescents. J Child Adolesc Psychopharmacol
. 2009;19(2):119-126. doi:10.1089/cap.2008.040PubMedGoogle ScholarCrossref
K , Cooper
PJ , Karalus
J , Voysey
M , Willetts
L , Creswell
C . Treatment of child anxiety disorders via guided parent-delivered cognitive-behavioural therapy: randomised controlled trial. Br J Psychiatry
. 2013;203(6):436-444. doi:10.1192/bjp.bp.113.126698PubMedGoogle ScholarCrossref
P , Marshall
T , Creswell
C . A randomized controlled trial of internet-delivered cognitive behaviour therapy for adolescent anxiety disorders in a routine clinical care setting with and without parent sessions. Child Adolesc Ment Health
. 2019;24(3):242-250. doi:10.1111/camh.12311PubMedGoogle ScholarCrossref
BM , Zavrou
S , Johnco
C , Storch
EA , Lewin
AB . Parent-led exposure therapy: a pilot study of a brief behavioral treatment for anxiety in young children. J Child Fam Stud
. 2017;26(9):2475-2484. doi:10.1007/s10826-017-0772-yGoogle ScholarCrossref
MA , Narayanan
M , Compton
SN , Kendall
PC , Neumer
S-P . Cognitive-behavioral therapy for youth anxiety: an effectiveness evaluation in community practice. J Consult Clin Psychol
. 2018;86(9):751-764. doi:10.1037/ccp0000326PubMedGoogle ScholarCrossref
DR , Masek
B , Henin
et al. Cognitive behavioral therapy for 4- to 7-year-old children with anxiety disorders: a randomized clinical trial. J Consult Clin Psychol
. 2010;78(4):498-510. doi:10.1037/a0019055PubMedGoogle ScholarCrossref
JR , Mills
JA , Schroeder
et al. Escitalopram in adolescents with generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. J Clin Psychiatry
. 2020;81(5):20m13396. doi:10.4088/JCP.20m13396PubMedGoogle ScholarCrossref
E , Senger
CA , Henninger
M , Gaynes
BN , Coppola
E , Soulsby Weyrich
M . US Preventive Services Task Force Evidence Syntheses, formerly Systematic Evidence Reviews. Interventions to Prevent Perinatal Depression: A Systematic Evidence Review for the US Preventive Services Task Force. Agency for Healthcare Research and Quality; 2019.