A 75-year-old woman presenting with decreased visual acuity and metamorphopsia in the right eye was referred for further evaluation of a pigmented epiretinal membrane. She had a history of cutaneous nodular melanoma in the right arm. Tumor staging was classified as T3N0M0 in August 2017, at the time of diagnosis and excision. In April 2018, axillary lymphadenectomy was performed for local recurrence and the patient started treatment with an immune checkpoint inhibitor (ICI) pembrolizumab, without further local or metastatic evidence of the tumor. Ocular history was positive for cataract surgery bilaterally. After cataract surgery in the right eye, an asymptomatic vision loss was noted and the cause was attributed to the presence of choroidal neovascularization (CNV), for which the patient underwent intravitreal anti–vascular endothelial growth factor (anti-VEGF) injections.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Corresponding Author: André Borges Silva, MD, Centro Hospitalar Tondela-Viseu, Av. Rei Dom Duarte, 3504-509 Viseu, Portugal (email@example.com).
Published Online: October 13, 2022. doi:10.1001/jamaophthalmol.2022.3949
Conflict of Interest Disclosures: Dr Figueira reported nonfinancial support from Alcon and Roche and personal fees from AbbVie, Alimera, Novartis, and Bayer outside the submitted work. No other disclosures were reported.
Additional Contributions: We thank Miguel Ribeiro, MD, for the patient referral, Nuno Gouveia, MD, who helped capture the optical coherence tomography and fundus images in the Ophthalmology Department, and Graça Fernandes, MD, and Barbara Sepodes, MD, who provided the photomicrograph showing cytopathologic results of epiretinal membrane biopsy sample. We also thank the patient for granting permission to publish this information.
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