[Skip to Content]
[Skip to Content Landing]

Association of Symptoms After COVID-19 Vaccination With Anti–SARS-CoV-2 Antibody Response in the Framingham Heart Study

Educational Objective
To identify the key insights or developments described in this article
1 Credit CME

SARS-CoV-2 messenger RNA (mRNA) vaccines (BNT162b2 [Pfizer-BioNTech] and mRNA-1273 [Moderna]) are associated with local and systemic symptoms; however, whether postvaccination symptoms are associated with vaccine-induced antibody response is unknown. Previous studies13 of COVID-19 vaccine reactogenicity and immunogenicity were limited to convenience samples that may not be generalizable. We studied the association of self-reported postvaccination symptoms with anti–SARS-CoV-2 antibody response among Framingham Heart Study (FHS) participants contributing to the Collaborative Cohort of Cohorts for COVID-19 Research (C4R) study.4

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 Credit(s)™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: September 7, 2022.

Published: October 21, 2022. doi:10.1001/jamanetworkopen.2022.37908

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Hermann EA et al. JAMA Network Open.

Corresponding Author: Emilia A. Hermann, MD, MPH, Division of General Medicine, Department of Medicine, Columbia University Medical Center, 630 W 168th St, PH 9 East, Room 105, New York, NY 10032 (eah2191@cumc.columbia.edu).

Author Contributions: Drs Hermann and Balte had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Hermann, Lee, Kirkpatrick, Oelsner.

Acquisition, analysis, or interpretation of data: Hermann, Balte, Xanthakis, Kirkpatrick, Cushman, Oelsner.

Drafting of the manuscript: Hermann, Lee, Kirkpatrick, Oelsner.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Hermann, Balte, Oelsner.

Obtained funding: Cushman, Oelsner.

Administrative, technical, or material support: Kirkpatrick, Cushman, Oelsner.

Supervision: Kirkpatrick, Oelsner.

Conflict of Interest Disclosures: Dr Balte reported receiving grants from the National Institutes of Health during the conduct of the study. Dr Oelsner reported receiving grants from the National Heart, Lung, and Blood Institute during the conduct of the study and outside the submitted work. No other disclosures were reported.

Funding/Support: This research was funded in part by agreement 1OT2HL156812 from the National Institutes of Health.

Role of the Funder/Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Disclaimer: The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the National Institutes of Health.

References
1.
Bauernfeind  S , Salzberger  B , Hitzenbichler  F ,  et al.  Association between reactogenicity and immunogenicity after vaccination with BNT162b2.   Vaccines (Basel). 2021;9(10):1089. doi:10.3390/vaccines9101089 PubMedGoogle ScholarCrossref
2.
Held  J , Esse  J , Tascilar  K ,  et al.  Reactogenicity correlates only weakly with humoral immunogenicity after COVID-19 vaccination with BNT162b2 mRNA (Comirnaty®).   Vaccines (Basel). 2021;9(10):1063. doi:10.3390/vaccines9101063 PubMedGoogle ScholarCrossref
3.
Hwang  YH , Song  KH , Choi  Y ,  et al.  Can reactogenicity predict immunogenicity after COVID-19 vaccination?   Korean J Intern Med. 2021;36(6):1486-1491. doi:10.3904/kjim.2021.210 PubMedGoogle ScholarCrossref
4.
Oelsner  EC , Krishnaswamy  A , Balte  PP ,  et al; for the C4R Investigators.  Collaborative cohort of cohorts for COVID-19 research (C4R) study: study design.   Am J Epidemiol. 2022;191(7):1153-1173. doi:10.1093/aje/kwac032 PubMedGoogle ScholarCrossref
5.
Styer  LM , Hoen  R , Rock  J ,  et al.  High-throughput multiplex SARS-CoV-2 IgG microsphere immunoassay for dried blood spots: a public health strategy for enhanced serosurvey capacity.   Microbiol Spectr. 2021;9(1):e0013421. doi:10.1128/Spectrum.00134-21 PubMedGoogle ScholarCrossref
6.
Debes  AK , Xiao  S , Colantuoni  E ,  et al.  Association of vaccine type and prior SARS-CoV-2 infection with symptoms and antibody measurements following vaccination among health care workers.   JAMA Intern Med. 2021;181(12):1660-1662. doi:10.1001/jamainternmed.2021.4580 PubMedGoogle ScholarCrossref
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Close
Close

Lookup An Activity

or

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close