SARS-CoV-2 messenger RNA (mRNA) vaccines (BNT162b2 [Pfizer-BioNTech] and mRNA-1273 [Moderna]) are associated with local and systemic symptoms; however, whether postvaccination symptoms are associated with vaccine-induced antibody response is unknown. Previous studies1- 3 of COVID-19 vaccine reactogenicity and immunogenicity were limited to convenience samples that may not be generalizable. We studied the association of self-reported postvaccination symptoms with anti–SARS-CoV-2 antibody response among Framingham Heart Study (FHS) participants contributing to the Collaborative Cohort of Cohorts for COVID-19 Research (C4R) study.4
Sign in to take quiz and track your certificates
JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 Credit(s)™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC
CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: September 7, 2022.
Published: October 21, 2022. doi:10.1001/jamanetworkopen.2022.37908
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Hermann EA et al. JAMA Network Open.
Corresponding Author: Emilia A. Hermann, MD, MPH, Division of General Medicine, Department of Medicine, Columbia University Medical Center, 630 W 168th St, PH 9 East, Room 105, New York, NY 10032 (email@example.com).
Author Contributions: Drs Hermann and Balte had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Hermann, Lee, Kirkpatrick, Oelsner.
Acquisition, analysis, or interpretation of data: Hermann, Balte, Xanthakis, Kirkpatrick, Cushman, Oelsner.
Drafting of the manuscript: Hermann, Lee, Kirkpatrick, Oelsner.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Hermann, Balte, Oelsner.
Obtained funding: Cushman, Oelsner.
Administrative, technical, or material support: Kirkpatrick, Cushman, Oelsner.
Supervision: Kirkpatrick, Oelsner.
Conflict of Interest Disclosures: Dr Balte reported receiving grants from the National Institutes of Health during the conduct of the study. Dr Oelsner reported receiving grants from the National Heart, Lung, and Blood Institute during the conduct of the study and outside the submitted work. No other disclosures were reported.
Funding/Support: This research was funded in part by agreement 1OT2HL156812 from the National Institutes of Health.
Role of the Funder/Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the National Institutes of Health.
You currently have no searches saved.
You currently have no courses saved.