As with airplane concepts, clinical trials fly or crash based on design engineering. Executing a well-designed trial that asks a clinically important question of a common problem is harder than it sounds. Vertiginous uplift requires gravity-defying kinetics by a dedicated and coordinated team, akin to climbing mountains. The final yards (writing and publishing) are, like the summit, the hardest, requiring commitment, focus, and an eye on the end game. Others in this fine series of articles on scientific endeavor covered the conceptualization, initiation, planning, and aggregation of trial data. Now it is time to publish (Box). What makes a trial stand out to editors and referees? Simplicity, as in nature, is the most elegant form to achieve.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Corresponding Author: Des C. Winter, MD, Division of Surgery, St Vincent’s University Hospital, Elm Park, Dublin 04, Ireland (firstname.lastname@example.org).
Published Online: October 26, 2022. doi:10.1001/jamasurg.2022.4910
Conflict of Interest Disclosures: Dr Haukoos reported personal fees from JAMA Surgery, Annals of Emergency Medicine, and the American College of Emergency Physicians outside the submitted work. No other disclosures were reported.
Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:
It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.
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