Prospective randomized clinical trials are considered to produce the highest-level evidence regarding intervention benefits for the health and well-being of the study population. Patient participation requires confidence and trust.
We live in a diverse society, characterized by a spectrum of genetic, lifestyle, and socioeconomic features that can influence efficacy of a drug or intervention. Research results cannot be generalized unless trial participants reflect the diversity of the large-scale community. An important first step in ensuring such representation involves having a clinical trial research team that is diverse and cognizant of overall population heterogeneity. Relevant research questions must be aligned with appropriate statistical plans.