[Skip to Content]
[Skip to Content Landing]

Combined Ophthalmic Artery and Central Retinal Vein Occlusion Secondary to Advanced Mantle Cell Lymphoma

To identify the key insights or developments described in this article
1 Credit CME

A 61-year-old female patient with treatment-resistant, end-stage mantle cell lymphoma and progressive central nervous system involvement with diffuse leptomeningeal lymphomatosis presented with sudden vision loss in the right eye for 2 weeks. On examination, visual acuity was no light perception OD. Fundus examination revealed severe, infiltrative optic neuropathy; ophthalmic artery occlusion with a cherry-red spot and macular edema; central retinal vein occlusion with dilated, cyanotic retinal veins and retinal hemorrhages in 4 quadrants; and preretinal, neoplastic vitreous seeding layering on a subhyaloid, preretinal, boat-shaped hemorrhage (Figure). Mantle cell lymphoma has a high recurrence rate and poor prognosis, with median survival ranging from 3 to 5 years from presentation.1 The ocular adnexal manifestations of mantle cell lymphoma have been described, but intraocular involvement is exceedingly rare.2 The patient’s retinal vascular compression resulted from an infiltrative neoplastic mass effect. Unfortunately, the patient died 3 weeks after presentation.

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 Credit(s)™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Timothy W. Olsen, MD, Department of Ophthalmology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (olsen.timothy@mayo.edu).

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient’s family for granting permission to publish this information.

References
1.
Cortelazzo  S , Ponzoni  M , Ferreri  AJ , Dreyling  M .  Mantle cell lymphoma.   Crit Rev Oncol Hematol. 2012;82(1):78-101. doi:10.1016/j.critrevonc.2011.05.001PubMedGoogle ScholarCrossref
2.
Iqbal  M , Castano  YG , Sher  T , Kharfan-Dabaja  MA .  Intraocular involvement of Mantle cell lymphoma: a case report and literature review.   Hematol Oncol Stem Cell Ther. 2021;14(2):147-152. doi:10.1016/j.hemonc.2019.03.002PubMedGoogle ScholarCrossref
AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 credit toward the CME [and Self-Assessment requirements] of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Close
Close

Lookup An Activity

or

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close