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Dermatology

Indurated Plaque With Ulceration on the Dorsum of the Left Hand

Educational Objective
Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.

1 Credit CME

JAMA Dermatology

Published Online: November 9, 2022

JAMA Dermatology Clinicopathological Challenge

Article Information and Disclosures

Juanjuan Li, MS¹;

Xiaomo Wu, PhD^1,2;

Borui Chen, MD, PhD^1,3

Author Affiliations

¹Dermatology Institute of Fuzhou, Dermatology Hospital of Fuzhou, Fuzhou, China
²Department of Biomedicine, University of Basel, Basel, Switzerland
³Research Center for Medical Mycology, Department of Dermatology, Peking University First Hospital, Peking University, Beijing, China

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A man in his 70s presented with a 6-month history of a rash on the left forearm, which gradually increased in severity. The patient developed a rash on the dorsal aspect of his hand half a year ago without any pain or itching discomfort and denied any history of injury or exposure to suspected pathogens prior to onset. After self-medication with topical herbal medicine, the lesions gradually spread to the forearm and fused into plaques, and ulcers often recurred on the surface. He denied any systemic symptoms and concerns. Physical examination revealed large, firm, mildly swollen erythematous plaques on the back of the left forearm with purulent discharge and crusting (Figure, A). Results of routine laboratory investigations, including complete blood cell count, biochemical profile, and chest radiography, were normal. A biopsy specimen was taken for pathological examination (Figure, B-D).

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A man in his 70s presented with a 6-month history of a rash on the left forearm, which gradually increased in severity. The patient developed a rash on the dorsal aspect of his hand half a year ago without any pain or itching discomfort and denied any history of injury or exposure to suspected pathogens prior to onset. After self-medication with topical herbal medicine, the lesions gradually spread to the forearm and fused into plaques, and ulcers often recurred on the surface. He denied any systemic symptoms and concerns. Physical examination revealed large, firm, mildly swollen erythematous plaques on the back of the left forearm with purulent discharge and crusting (Figure, A). Results of routine laboratory investigations, including complete blood cell count, biochemical profile, and chest radiography, were normal. A biopsy specimen was taken for pathological examination (Figure, B-D).

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Article Information

Corresponding Author: Borui Chen, MD, PhD, Dermatology Institute of Fuzhou, Dermatology Hospital of Fuzhou, Xihong Rd 243, Fuzhou 350025, China (pekking@gmail.com).

Published Online: November 9, 2022. doi:10.1001/jamadermatol.2022.4889

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information. We also thank Jun Chen, MD, Liqiang Weng, MD, and Qinqin Long, MD, all from the Dermatology Hospital of Fuzhou, for their assistance in pathology; Wanding Lu, MD, from the Dermatology Hospital of Fuzhou, for assisting in professional guidance and comments on this case; and Xi Lin, MS, from the Public Technology Service Center of Fujian Medical University, for support in transmission electron microscopy. They were not compensated for their contributions.

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 credit toward the CME of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.