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Cardiology

Diagnosis and Management of Hereditary Hemochromatosis

To identify the key insights or developments described in this article

1 Credit CME

JAMA

Published Online: November 8, 2022

JAMA Insights

Article Information and Disclosures

Elizabeth Cabrera, MD¹;

Gonzalo Crespo, MD²;

Lisa B. VanWagner, MD, MSc³

Author Affiliations

¹Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
²Liver Unit, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Spain
³Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas

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Article Information

Corresponding Author: Lisa B. VanWagner, MD, MSc, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, 5959 Harry Hines Blvd, Ste HP4.420M, Dallas, TX 75390 (lisa.vanwagner@utsouthwestern.edu).

Conflict of Interest Disclosures: Dr VanWagner reported receiving investigator-initiated grant support from W.L. Gore & Associates and grants from Intercept Pharmaceuticals, Enanta Pharmaceuticals, Madrigal Pharmaceuticals, and AMRA Medical; consulting for Noble Insights and Gerson Lehrman Group; and serving as an expert witness outside the submitted work. No other disclosures were reported.

References

Kowdley KV , Brown KE , Ahn J , Sundaram V . ACG clinical guideline: hereditary hemochromatosis. Am J Gastroenterol. 2019;114(8):1202-1218.PubMed Google Scholar Crossref

Atkins JL , Pilling LC , Masoli JAH , et al. Association of hemochromatosis HFE p.C282Y homozygosity with hepatic malignancy. JAMA. 2020;324(20):2048-2057.PubMed Google Scholar Crossref

Kane SF , Roberts C , Paulus R . Hereditary hemochromatosis: rapid evidence review. Am Fam Physician. 2021;104(3):263-270.PubMed Google Scholar

Bacon BR , Adams PC , Kowdley KV , et al. Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology. 2011;54(1):328-343.PubMed Google Scholar Crossref

Kawabata H . The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis. Int J Hematol. 2018;107(1):31-43. doi:10.1007/s12185-017-2365-3 PubMed Google Scholar Crossref

Palmer WC , Vishnu P , Sanchez W , et al. Diagnosis and management of genetic iron overload disorders. J Gen Intern Med. 2018;33(12):2230-2236.PubMed Google Scholar Crossref

VanWagner LB , Green RM . Elevated serum ferritin. JAMA. 2014;312(7):743-744.PubMed Google Scholar Crossref

European Association for the Study of the Liver. EASL clinical practice guidelines on haemochromatosis. J Hepatol. 2022;77(2):479-502.PubMed Google Scholar Crossref

Bardou-Jacquet E , Morandeau E , Anderson GJ , et al. Regression of fibrosis stage with treatment reduces long-term risk of liver cancer in patients with hemochromatosis caused by mutation in HFE. Clin Gastroenterol Hepatol. 2020;18(8):1851-1857. PubMed Google Scholar Crossref

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.