Accepted for Publication: September 23, 2022.
Published: November 9, 2022. doi:10.1001/jamanetworkopen.2022.40993
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Flannery DD et al. JAMA Network Open.
Corresponding Author: Karen M. Puopolo, MD, PhD, Children's Hospital of Philadelphia Newborn Care at Pennsylvania Hospital, 800 Spruce St., Philadelphia, PA 19107 (firstname.lastname@example.org).
Author Contributions: Drs Dhudasia and Puopolo had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Flannery and Gouma contributed equally to this work.
Concept and design: Flannery, Gouma, Dhudasia, Gerber, Hensley, Puopolo.
Acquisition, analysis, or interpretation of data: Flannery, Gouma, Dhudasia, Mukhopadhyay, Pfeifer, Woodford, Briker, Triebwasser, Gerber, Morris, Weirick, McAllister, Puopolo.
Drafting of the manuscript: Flannery, Dhudasia, Puopolo.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Flannery, Dhudasia, Mukhopadhyay, Morris.
Obtained funding: Hensley, Puopolo.
Administrative, technical, or material support: Flannery, Gouma, Pfeifer, Woodford, Weirick, McAllister, Puopolo.
Supervision: Mukhopadhyay, Gerber, Hensley, Puopolo.
Conflict of Interest Disclosures: Dr Flannery reported receiving grants from the Agency for Healthcare Research and Quality and the Centers for Disease Control and Prevention (CDC) outside the submitted work. Dr Mukhopadhyay reported receiving a grant from Eunice Kennedy Shriver National Institute of Child Health and Human Development outside the submitted work. Dr Hensley reported receiving grants from the National Institute of Allergy and Infectious Diseases outside the submitted work. Dr Puopolo reported receiving grants from the National Institutes of Health and the CDC outside the submitted work. No other disclosures were reported.
Funding/Support: This study was funded in part by a Foerderer Grant for Excellence from the Children’s Hospital of Philadelphia (Drs Puopolo and Flannery).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Meeting Presentation: The interim results of this study were presented at the Pediatric Academic Societies Annual Meeting; April 23, 2022; Denver, Colorado. The final results were presented at the American Academy of Pediatrics National Conference and Exhibition; October 8, 2022; Anaheim, California.
Additional Contributions: Jeffrey Lurie, the Philadelphia Eagles, and Joel Embiid, Josh Harris, and David Blitzer, the Philadelphia 76ers, provided philanthropic support to establish the serological assays used in this study. Florian Krammer, PhD, Mt. Sinai, provided the SARS-CoV-2 spike receptor-binding domain expression plasmids. Ian Wilson, DPhil, Scripps, provided plasmids to express monoclonal CR3022. These individuals received no additional compensation, outside of their usual salary, for their contributions.
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