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Guidelines

Diagnosis and Treatment of Infertility in Men

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1 Credit CME

JAMA

Published Online: November 22/29, 2022

JAMA Clinical Guidelines Synopsis

Article Information and Disclosures

Joshua A. Halpern, ME, MS¹;

Andrew M. Davis, MD, MPH²;

Robert E. Brannigan, MD¹

Author Affiliations

¹Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
²Section of General Internal Medicine, University of Chicago Medicine, Chicago, Illinois

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Article Information

Corresponding Author: Andrew M. Davis, MD, MPH, Section of General Internal Medicine, University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637 (amd@uchicago.edu).

Conflict of Interest Disclosures: Dr Halpern reported serving as an investigator for an ongoing clinical trial in male infertility for Ferring Pharmaceuticals Inc and board of director member for the Society of Male Reproduction and Urology, an affiliate organization of the ASRM. Dr Brannigan reported serving as co-investigator of a clinical trial for Ferring Pharmaceuticals, receiving personal fees from the American Board of Urology, and serving on an editorial committee for the AUA. No other disclosures were reported.

Additional Contributions: We acknowledge the contributions of Richard J. Fantus, MD, in the development of this article, for which he was not compensated.

References

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Schlegel PN , Sigman M , Collura B , et al. Diagnosis and treatment of infertility in men: AUA/ASRM guideline part II. J Urol. 2021;205(1):44-51.PubMed Google Scholar Crossref

World Health Organization Task Force on Methods for the Regulation of Male Fertility. Contraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal men. Fertil Steril. 1996;65(4):821-829.PubMed Google Scholar Crossref

Meistrich ML . Effects of chemotherapy and radiotherapy on spermatogenesis in humans. Fertil Steril. 2013;100(5):1180-1186.PubMed Google Scholar Crossref

Wang J , Xia SJ , Liu ZH , et al. Inguinal and subinguinal micro-varicocelectomy, the optimal surgical management of varicocele. Asian J Androl. 2015;17(1):74-80.PubMed Google Scholar

Bernie AM , Mata DA , Ramasamy R , Schlegel PN . Comparison of microdissection testicular sperm extraction, conventional testicular sperm extraction, and testicular sperm aspiration for nonobstructive azoospermia. Fertil Steril. 2015;104(5):1099-103.e1, 3.PubMed Google Scholar Crossref

Abdel-Meguid TA , Al-Sayyad A , Tayib A , Farsi HM . Does varicocele repair improve male infertility? Eur Urol. 2011;59(3):455-461.PubMed Google Scholar Crossref

Uvin V , De Brucker S , De Brucker M , et al. Pregnancy after vasectomy. Hum Reprod. 2018;33(7):1218-1227.PubMed Google Scholar

Amer M , Ateyah A , Hany R , Zohdy W . Prospective comparative study between microsurgical and conventional testicular sperm extraction in non-obstructive azoospermia. Hum Reprod. 2000;15(3):653-656.PubMed Google Scholar Crossref

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 credit toward the CME [and Self-Assessment requirements] of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.