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Diagnosis and Treatment of Infertility in Men

To identify the key insights or developments described in this article
1 Credit CME

Infertility affects about 15% of couples and is due to a male factor alone in 20% and combined male and female factors in 30% to 40%.1 In 25% of couples, no clear cause for infertility can be identified. This guideline addresses the evaluation of male infertility, which can arise from a wide array of conditions, and discusses issues that may affect infertility treatment or the health of the patient and offspring.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Andrew M. Davis, MD, MPH, Section of General Internal Medicine, University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637 (amd@uchicago.edu).

Conflict of Interest Disclosures: Dr Halpern reported serving as an investigator for an ongoing clinical trial in male infertility for Ferring Pharmaceuticals Inc and board of director member for the Society of Male Reproduction and Urology, an affiliate organization of the ASRM. Dr Brannigan reported serving as co-investigator of a clinical trial for Ferring Pharmaceuticals, receiving personal fees from the American Board of Urology, and serving on an editorial committee for the AUA. No other disclosures were reported.

Additional Contributions: We acknowledge the contributions of Richard J. Fantus, MD, in the development of this article, for which he was not compensated.

References
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2.
Schlegel  PN , Sigman  M , Collura  B ,  et al.  Diagnosis and treatment of infertility in men: AUA/ASRM guideline part II.   J Urol. 2021;205(1):44-51.PubMedGoogle ScholarCrossref
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World Health Organization Task Force on Methods for the Regulation of Male Fertility.  Contraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal men.   Fertil Steril. 1996;65(4):821-829.PubMedGoogle ScholarCrossref
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