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Skin Cancer

Vulvar Melanoma

To identify the key insights or developments described in this article

1 Credit CME

JAMA Dermatology

Published Online: November 30, 2022

Images in Dermatology

Article Information and Disclosures

Isobel M. Pye, MD, BMed, MPhil¹;

Robyn P. M. Saw, MS, MBBS^2,3,4;

Rebecca Bronwyn Saunderson, BMedSci, MBBS, MPhil^1,4

Author Affiliations

¹Royal North Shore Hospital, Sydney, New South Wales, Australia
²Melanoma Institute Australia, Sydney, New South Wales, Australia
³Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
⁴The University of Sydney, Sydney, New South Wales, Australia

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A woman in her 40s presented for evaluation of a nodule associated with dark discoloration on her labia minora. She noticed these changes 5 months prior and had associated pain over the site with dysuria. Examination revealed an ulcerated, erythematous, and hyperpigmented periurethral nodule (10 × 10 mm) with surrounding irregular macular hyperpigmentation (Figure). Dermatoscopy revealed multiple colors, a blue-gray veil, and no pigment network.

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Article Information

Corresponding Author: Isobel M. Pye, MD, BMed, Royal North Shore Hospital, Reserve Road, St Leonards NSW 2065, Australia (isobel.m.pye@gmail.com).

Published Online: November 30, 2022. doi:10.1001/jamadermatol.2022.4550

Conflict of Interest Disclosures: Dr Saw reported personal fees from Novartis, MSD, Qbiotics, and BMS outside the submitted work. No other disclosures were reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References

Boer FL , Ten Eikelder MLG , van Geloven N , et al. Evaluation of treatment, prognostic factors, and survival in 198 vulvar melanoma patients: Implications for clinical practice. Gynecol Oncol. 2021;161(1):202-210.PubMed Google Scholar Crossref

Hu DN , Yu GP , McCormick SA . Population-based incidence of vulvar and vaginal melanoma in various races and ethnic groups with comparisons to other site-specific melanomas. Melanoma Res. 2010;20(2):153-158.PubMed Google Scholar Crossref

De Giorgi V , Gori A , Salvati L , et al. Clinical and dermoscopic features of vulvar melanosis over the last 20 years. JAMA Dermatol. 2020;156(11):1185-1191.PubMed Google Scholar Crossref

National Comprehensive Cancer Network. Cutaneous melanoma (version 3), 2022. Accessed June 29, 2022. https://www.nccn.org/professionals/physician_gls/pdf/cutaneous_melanoma.pdf

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.