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A Peculiar ST Elevation Mimicking STEMI

To identify the key insights or developments described in this article
1 Credit CME

A patient in their 60s presented to the emergency department with a 2-week history of shortness of breath and back pain exacerbated that morning. The medical history was noteworthy for a remote history of cervical cancer. The patient was recently found to have a vesicovaginal fistula and metastatic lesions in the liver and lungs. Percutaneous bilateral nephrostomies were placed weeks before presentation. The patient also had a history of 40 pack-years of smoking but no known cardiovascular disease. On admission, blood pressure was 105/65 mm Hg, heart rate was 94 beats per minute, and respiratory rate was 16 breaths per minute. Jugular veins were mildly elevated, and cardiac examination was notable for a gallop and a soft systolic ejection murmur. Lung examination demonstrated basilar crackles, and there was grade 2 and higher lower-extremity edema. A 12-lead electrocardiogram (ECG) was performed on arrival (Figure).

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The ST elevation’s peculiar morphology is known as the spiked helmet sign (SHS) due to its resemblance to the military helmet, the Pickelhaube.1 It is characterized by an upward shift preceding the QRS complex, which has a sharp R wave followed by a convex ST elevation.2

The spiked morphology is given by the QRS complexes buried in the dome-shaped pseudo–ST elevation. This STEMI mimic is characterized by an upsloping shift preceding the QRS complex, which appears to align with the ST elevation. In the present case, the upsloping shift was observed in V4 through V6 and the convex dome-shaped pseudo–ST elevation in the inferior leads and from V4 through V6.

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Article Information

Corresponding Author: Jose Victor Jimenez, MD, Department of Internal Medicine, Yale New Haven Hospital, 20 York St, New Haven, CT 06510 (josevictor.jimenezceja@yale.edu).

Published Online: December 27, 2022. doi:10.1001/jamainternmed.2022.5070

Conflict of Interest Disclosures: Dr Desai reported grants from Amgen, AstraZeneca, Boehringer Ingelheim, Cytokinetics, Novartis, and Vifor, as well as personal fees from Bayer, Bristol Myers Squibb, and scPharmaceuticals outside the submitted work. No other disclosures were reported.

References
1.
Littmann  L , Monroe  MH .  The “spiked helmet” sign: a new electrocardiographic marker of critical illness and high risk of death.   Mayo Clin Proc. 2011;86(12):1245-1246. doi:10.4065/mcp.2011.0647 PubMedGoogle ScholarCrossref
2.
Crinion  D , Abdollah  H , Baranchuk  A .  An ominous ECG sign in critical care.   Circulation. 2020;141(25):2106-2109. doi:10.1161/CIRCULATIONAHA.120.047427 PubMedGoogle ScholarCrossref
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Oluyadi  F , Kariyanna  PT , Jayarangaiah  A , Celenza-Salvatore  J , McFarlane  IM .  Helmet sign on EKG: a rare indicator of poor prognosis in critically ill patients.   Am J Med Case Rep. 2019;7(10):260-263. doi:10.12691/ajmcr-7-10-9 PubMedGoogle ScholarCrossref
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Samadov  F , Gasimov  E , Aliyev  F , Isayev  E .  The “Spiked Helmet” sign—a potential relationship to Takotsubo cardiomyopathy.   Am J Emerg Med. 2018;36(2):345.e5-345.e7. doi:10.1016/j.ajem.2017.11.041PubMedGoogle ScholarCrossref
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Madias  JE .  Towards a resolution of the mechanism of “spiked helmet ECG sign” in takotsubo syndrome and other acute life-threatening illnesses?   J Electrocardiol. 2019;55:155-156. doi:10.1016/j.jelectrocard.2019.05.004 PubMedGoogle ScholarCrossref
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Littmann  L .  The electrocardiographic spiked helmet sign: is it real, artifact, or optical illusion?   J Electrocardiol. 2019;55:152-154. doi:10.1016/j.jelectrocard.2019.06.002 PubMedGoogle ScholarCrossref
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Ghadri  JR , Wittstein  IS , Prasad  A ,  et al.  International expert consensus document on Takotsubo syndrome (part I): clinical characteristics, diagnostic criteria, and pathophysiology.   Eur Heart J. 2018;39(22):2032-2046. doi:10.1093/eurheartj/ehy076 PubMedGoogle ScholarCrossref
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Singh  T , Khan  H , Gamble  DT , Scally  C , Newby  DE , Dawson  D .  Takotsubo syndrome: pathophysiology, emerging concepts, and clinical implications.   Circulation. 2022;145(13):1002-1019. doi:10.1161/CIRCULATIONAHA.121.055854 PubMedGoogle ScholarCrossref
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Frangieh  AH , Obeid  S , Ghadri  JR ,  et al; InterTAK Collaborators.  ECG criteria to differentiate between Takotsubo (stress) cardiomyopathy and myocardial infarction.   J Am Heart Assoc. 2016;5(6):e003418. doi:10.1161/JAHA.116.003418 PubMedGoogle ScholarCrossref
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Di Vece  D , Citro  R , Cammann  VL ,  et al.  Outcomes associated with cardiogenic shock in takotsubo syndrome.   Circulation. 2019;139(3):413-415. doi:10.1161/CIRCULATIONAHA.118.036164 PubMedGoogle ScholarCrossref
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