[Skip to Content]
[Skip to Content Landing]

Large Bilateral Compressible Neck Mass in 55-Year-Old Man

Educational Objective
Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.
1 Credit CME

A 55-year-old male jazz musician with a medical history that was significant for hypertension, coronary artery disease, and obstructive sleep apnea presented with an enlarging right more than left-sided neck mass of more than 2 years’ duration. The patient was seen and evaluated by a local surgical oncologist with a working diagnosis of possible lymphoma. The growing neck mass was causing solid food dysphagia and difficulty breathing at night. He did not have any neurological deficits. On further questioning, he had a similar mass that was treated with liposuction 10 years prior. His family history was negative for any head and neck benign or malignant disease. His social history was negative for tobacco or alcohol use. This patient was not taking any steroid medications.

Please finish quiz first before checking answer.

You answered correctly!

Read the answer below and download your certificate.

You answered incorrectly.

Read the discussion below and retake the quiz.

A 55-year-old male jazz musician with a medical history that was significant for hypertension, coronary artery disease, and obstructive sleep apnea presented with an enlarging right more than left-sided neck mass of more than 2 years’ duration. The patient was seen and evaluated by a local surgical oncologist with a working diagnosis of possible lymphoma. The growing neck mass was causing solid food dysphagia and difficulty breathing at night. He did not have any neurological deficits. On further questioning, he had a similar mass that was treated with liposuction 10 years prior. His family history was negative for any head and neck benign or malignant disease. His social history was negative for tobacco or alcohol use. This patient was not taking any steroid medications.

Survey Complete!

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 Credit(s)™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Tom Thomas, MD, MPH, Head and Neck Reconstructive Surgery, Morristown Medical Center, 100 Madison Ave, Morristown, NJ 07960 (tom.thomas@atlantichealth.org).

Published Online: December 22, 2022. doi:10.1001/jamaoto.2022.4237

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References:
1.
Amicucci  G , Sozio  ML , Rizzo  FM , Sozio  A .  Malattia di Madelung: caso clinico e revisione della letteratura.   Minerva Chir. 1998;53(7-8):655-657.PubMedGoogle Scholar
2.
Chuang  CC , Cheng  YF , Chang  HP , Lin  CZ .  Madelung’s disease.   J Chin Med Assoc. 2004;67(11):591-594.PubMedGoogle Scholar
3.
Ray  S , Chakraborty  PP , Pramanik  S , Chowdhury  S .  Bilateral breast enlargement in a chronic alcoholic: do not miss Madelung’s disease.   BMJ Case Rep. 2016;2016:bcr2016215082. doi:10.1136/bcr-2016-215082 PubMedGoogle ScholarCrossref
4.
González-García  R , Rodríguez-Campo  FJ , Sastre-Pérez  J , Muñoz-Guerra  MF .  Benign symmetric lipomatosis (Madelung’s disease): case reports and current management.   Aesthetic Plast Surg. 2004;28(2):108-112. doi:10.1007/s00266-004-3123-5 PubMedGoogle ScholarCrossref
5.
Economides  NG , Liddell  HT .  Benign symmetric lipomatosis (Madelung’s disease).   South Med J. 1986;79(8):1023-1025. doi:10.1097/00007611-198608000-00027 PubMedGoogle ScholarCrossref
6.
Gámez  J , Playán  A , Andreu  AL ,  et al.  Familial multiple symmetric lipomatosis associated with the A8344G mutation of mitochondrial DNA.   Neurology. 1998;51(1):258-260. doi:10.1212/WNL.51.1.258 PubMedGoogle ScholarCrossref
7.
Pauchot  J , Golay  A , Gumener  R , Montandon  D , Pittet  B .  La maladie de Launois-Bensaude : description, prise en charge: a propos de dix patients opérés.   Ann Chir Plast Esthet. 2009;54(2):135-145. doi:10.1016/j.anplas.2008.07.004 PubMedGoogle ScholarCrossref
8.
Enzi  G , Busetto  L , Sergi  G ,  et al.  Multiple symmetric lipomatosis: a rare disease and its possible links to brown adipose tissue.   Nutr Metab Cardiovasc Dis. 2015;25(4):347-353. doi:10.1016/j.numecd.2015.01.010 PubMedGoogle ScholarCrossref
9.
Brea-García  B , Cameselle-Teijeiro  J , Couto-González  I , Taboada-Suárez  A , González-Álvarez  E .  Madelung’s disease: comorbidities, fatty mass distribution, and response to treatment of 22 patients.   Aesthetic Plast Surg. 2013;37(2):409-416. doi:10.1007/s00266-012-9874-5 PubMedGoogle ScholarCrossref
AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 credit toward the CME of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Close
Close

Lookup An Activity

or

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close