[Skip to Content]
[Skip to Content Landing]

Values and Preferences of Patients and Caregivers Regarding Treatment of Atopic Dermatitis (Eczema)A Systematic Review

To identify the key insights or developments described in this article
1 Credit CME
Key Points

Question  What do patients and caregivers value when choosing treatments for atopic dermatitis?

Findings  In this systematic synthesis of 62 studies including 19 442 participants, patients and caregivers preferred avoiding adverse effects and valued treatment approaches that relieve itching and burning, are minimally disruptive to daily activities, have limited visibility, and sparingly use topical corticosteroids. Some studies presented varied perspectives, and 18 were at high risk for industry sponsorship bias.

Meaning  In the first systematic review to address patient values and preferences in the management of atopic dermatitis to our knowledge, 6 key themes that may inform optimal clinical care, practice guidelines, and future research have been identified.

Abstract

Importance  Patient values and preferences can inform atopic dermatitis (AD) care. Systematic summaries of evidence addressing patient values and preferences have not previously been available.

Objective  To inform American Academy of Allergy, Asthma & Immunology (AAAAI)/American College of Allergy, Asthma and Immunology (ACAAI) Joint Task Force on Practice Parameters AD guideline development, patient and caregiver values and preferences in the management of AD were systematically synthesized.

Evidence Review  Paired reviewers independently screened MEDLINE, Embase, PsycINFO, and CINAHL databases from inception until March 20, 2022, for studies of patients with AD or their caregivers, eliciting values and preferences about treatment, rated risk of bias, and extracted data. Thematic and inductive content analysis to qualitatively synthesize the findings was used. Patients, caregivers, and clinical experts provided triangulation. The GRADE-CERQual (Grading of Recommendations Assessment, Development and Evaluation–Confidence in the Evidence from Reviews of Qualitative Research) informed rating of the quality of evidence.

Findings  A total of 7780 studies were identified, of which 62 proved eligible (n = 19 442; median age across studies [range], 15 years [3-44]; 59% female participants). High certainty evidence showed that patients and caregivers preferred to start with nonmedical treatments and to step up therapy with increasing AD severity. Moderate certainty evidence showed that adverse effects from treatment were a substantial concern. Low certainty evidence showed that patients and caregivers preferred odorless treatments that are not visible and have a minimal effect on daily life. Patients valued treatments capable of relieving itching and burning skin and preferred to apply topical corticosteroids sparingly. Patients valued a strong patient-clinician relationship. Some studies presented varied perspectives and 18 were at high risk for industry sponsorship bias.

Conclusions and Relevance  In the first systematic review to address patient values and preferences in management of AD to our knowledge, 6 key themes that may inform optimal clinical care, practice guidelines, and future research have been identified.

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 Credit(s)™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Accepted for Publication: November 17, 2022.

Published Online: January 25, 2023. doi:10.1001/jamadermatol.2022.6045

Corresponding Author: Derek K. Chu, MD, PhD, Department of Medicine, McMaster University. Room 3H30 McMaster University Medical Centre, 1280 Main St West, Hamilton, Ontario, Canada (chudk@mcmaster.ca).

Author Contributions: Drs Maleki-Yazdi and Chu had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Maleki-Yazdi, Heen, Zhao, Guyatt, Makhdami, Winders, Wheeler, Spergel, Silverberg, Ong, LeBovidge, Frazier, Capozza, De Benedetto, Schneider, Chu.

Acquisition, analysis, or interpretation of data: Maleki-Yazdi, Heen, Zhao, Suzumura, Makhdami, Chen, Wang, Silverberg, Ong, O'Brien, Martin, Lio, Lind, Kim, Huynh, Greenhawt, Ellison, Boguniewicz, Smith Begolka, Asiniwasis, Schneider, Chu.

Drafting of the manuscript: Maleki-Yazdi, Heen, Zhao, Makhdami, Kim, Huynh, Frazier, Ellison, Chu.

Critical revision of the manuscript for important intellectual content: Maleki-Yazdi, Heen, Zhao, Guyatt, Suzumura, Makhdami, Chen, Winders, Wheeler, Wang, Spergel, Silverberg, Ong, O'Brien, Martin, Lio, Lind, LeBovidge, Greenhawt, Capozza, De Benedetto, Boguniewicz, Smith Begolka, Asiniwasis, Schneider, Chu.

Statistical analysis: Maleki-Yazdi, Zhao, Makhdami, Winders, Wheeler, Chu.

Obtained funding: Chu.

Administrative, technical, or material support: Maleki-Yazdi, Zhao, Makhdami, Chen, O'Brien, Schneider, Chu.

Supervision: Maleki-Yazdi, Heen, Guyatt, Wang, Spergel, Ong, Greenhawt, Frazier, De Benedetto, Chu.

Conflict of Interest Disclosures: Dr Wang reported grants from DBV Technologies, Aimmune, and Regeneron; and personal fees from ALK Abello, Genentech, and Jubilant HollisterStier outside the submitted work. Mrs Winders reported that her institution has received funding for unbranded disease awareness and education from the following: AbbVie, ALK, Amgen, AstraZeneca, Incyte, Lilly, GSK, Novartis, Pfizer, Sanofi/Regeneron, and TEVA. Dr Spergel reported grants from Abbott, Food Allergy Research and Education, Novartis, Regeneron, Sanofi, and Takeda; and royalties from UpToDate outside the submitted work. Dr Spergel also reported receiving payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from Medscape and Rockpointe; and being on the safety monitoring board or advisory board of the National Institute of Allergy and Infectious Disease and Syneos. Dr Silverberg reported personal fees from AbbVie, AObiome, Arcutis, Alamar, Amgen, Arena, Arcutis, Asana, Aslan, BioMX, Biosion, Bodewell, Boehringer-Ingelheim, Cara, Castle Biosciences, Celgene, Connect Biopharma, Dermavant, Dermira, Dermtech, Eli Lilly, Galderma, GlaxoSmithKline, Incyte, Kiniksa, Leo Pharma, Menlo, Novartis, Optum, Pfizer, RAPT, Regeneron, Sanofi Genzyme, Shaperon, Union; and grants from Incyte and Pfizer outside the submitted work. Dr Ong reported grants from Incyte, LEO Pharmaceuticals, Regeneron, Sanofi Genzyme; and personal fees from Incyte, Janssen, Sanofi Genzyme, AbbVie, and Pfizer outside the submitted work. Dr Lio reported personal fees for serving on advisory boards for Almirall, Arbonne, ASLAN Pharmaceuticals, Bodewell, Boston Skin Science, Bristol Myers Squibb, Burt's Bees, Castle Biosciences, Codex Labs, Concerto Biosciences, Dermavant, Dermira, Exeltis, Franklin Biosciences, IntraDerm, Janssen, Johnson & Johnson, Kaleido Biosciences, Kimberly-Clark, Kiniksa, KPAway, Level Ex, Lipidor, Menlo Therapeutics, Merck, Micreos Health, My-Or Diagnostics, Procter & Gamble, Realm Therapeutics, Skinfix, UCB, Unilever, Verrica; for serving on an advisory board, as a speaker, and an investigator for AbbVie and Regeneron; for serving as a consultant for Amyris; for serving as an advisor and investigator for AOBiome; for serving on an advisory board and as a speaker for Eli Lilly, Galderma, La Roche-Posay, LEO Pharmaceuticals, L'Oreal, MyOR Diagnostics, Pfizer, Pierre-Fabre, Sanofi; for serving as a speaker for Hyphens Pharma, Genzyme, and Incyte; grants from the Eczema Foundation and National Eczema Association (NEA) for serving as an investigator. Dr Lio also served on the board of directors for the NEA, served on the advisory board for Theraplex (with a patent pending with royalties paid), is an investor at LearnSkin, and has stock options from the following companies: Altus Health, Boston Skin Science, Concerto Biosciences, Franklin Biosciences (aka Altus labs), and Micreos Health. Dr LeBovidge reported grants from Pfizer to develop atopic dermatitis (AD) patient education materials (unrestricted educational grant) outside the submitted work. Dr Greenhawt is a member of physician and medical advisory boards for Sanofi/Regeneron, Genentech, Novartis, Pfizer, US World Meds; has received honoraria for lectures from ImSci and the MedLearningGroup; reported personal fees from DBV, Pfizer, Novartis, Aquestive, Nutricia, Sanofi/Regeneron, Genentech, Allergy Therapeutics, ALK-Abello, US World Meds, Allegenis, Prota, AstraZeneca, RMSI, and multiple state and local allergy societies; and nonfinancial support from the National Peanut Board, International Food Protein Induced Enterocolitis Syndrome Association, American College of Allergy Asthma and Immunology (ACAAI), Joint Task Force on Practice Parameters (JTFPP), Brighton Collaboration Criteria Vaccine Anaphylaxis 2.0 working group; and grants from Agency for Healthcare Quality and Research (support ended in 2020) outside the submitted work. Mrs Capozza reported grants from LEO Pharmaceuticals, Sanofi/Regeneron, Incyte, Galderma, AbbVie, Lilly; and personal fees from Incyte and Sanofi/Regeneron outside the submitted work. Dr De Benedetto is an investigator for Dermira and Novartis; reported grants from Pfizer and Kiniksa; and personal fees from dMed Biopharmaceutical Co, Ltd (consultant) outside the submitted work. Dr Boguniewicz conducts research at Regeneron and Incyte and is part of advisory boards and consults for AbbVie, Janssen, LEO Pharmaceuticals, Lilly, Pfizer, Regeneron, Sanofi, and Genzyme outside the submitted work. Ms Smith Begolka reported grants from Pfizer paid to the institution, personal fees from Pfizer and Incyte paid to NEA, and being a salaried employee for NEA outside the submitted work. Dr Schneider reported grants from Regeneron Pharmaceuticals paid to the institution and Pfizer paid to a colleague; personal fees for serving on an advisory board from Sanofi and LEO Pharmaceuticals; and has served on the advisory board for the NEA outside the submitted work. No other disclosures were reported.

Funding/Support: This work was commissioned by the American Academy of Allergy, Asthma & Immunology (AAAAI) and ACAAI through the JTFPP to inform upcoming guidance on management of AD.

Role of the Funder/Sponsor: The funder contributed to defining the scope of the review but otherwise had no role in study design and data collection. Data were interpreted and the report drafted and submitted without funder input. The funder was provided a copy of the report at time of submission. The review team had the ability, but not obligation, to consider the funder’s feedback. The first and corresponding author had full access to all data in the study and had final responsibility for the decision to submit for publication.

Additional Contributions: We thank all the patients and caregiver partners part of the 2022 AAAAI/ACAAI JTFPP Atopic Dermatitis Guidelines.

Disclaimer: The authors, editors, and journal take a neutral position with respect to territorial claims in published maps and institutional affiliations.

References
1.
Boguniewicz  M , Fonacier  L , Guttman-Yassky  E , Ong  PY , Silverberg  J , Farrar  JR .  Atopic dermatitis yardstick: practical recommendations for an evolving therapeutic landscape.   Ann Allergy Asthma Immunol. 2018;120(1):10-22.e2. doi:10.1016/j.anai.2017.10.039PubMedGoogle ScholarCrossref
2.
Bakaa  L , Pernica  JM , Couban  RJ ,  et al.  Bleach baths for atopic dermatitis: a systematic review and meta-analysis including unpublished data, Bayesian interpretation, and GRADE.   Ann Allergy Asthma Immunol. 2022;128(6):660-668.e9. doi:10.1016/j.anai.2022.03.024PubMedGoogle ScholarCrossref
3.
Oykhman  P , Dookie  J , Al-Rammahy  H ,  et al.  Dietary elimination for the treatment of atopic dermatitis: a systematic review and meta-analysis.   J Allergy Clin Immunol Pract. 2022;10(10):2657-2666.e8. doi:10.1016/j.jaip.2022.06.044PubMedGoogle ScholarCrossref
4.
Chu  DK , Golden  DBK , Guyatt  GH .  Translating evidence to optimize patient care using GRADE.   J Allergy Clin Immunol Pract. 2021;9(12):4221-4230. doi:10.1016/j.jaip.2021.09.035PubMedGoogle ScholarCrossref
5.
Schneider  L , Tilles  S , Lio  P ,  et al.  Atopic dermatitis: a practice parameter update 2012.   J Allergy Clin Immunol. 2013;131(2):295-9.e1, 27. doi:10.1016/j.jaci.2012.12.672PubMedGoogle ScholarCrossref
6.
Agarwal  A , Chen  L , Capozza  K ,  et al.  Trustworthy patient-centered guidelines: insights from atopic dermatitis and a proposal for the future.   J Allergy Clin Immunol Pract. 2022;10(11):2875-2877. doi:10.1016/j.jaip.2022.06.017PubMedGoogle ScholarCrossref
7.
Thomas  J , Harden  A .  Methods for the thematic synthesis of qualitative research in systematic reviews.   BMC Med Res Methodol. 2008;8:45. doi:10.1186/1471-2288-8-45PubMedGoogle ScholarCrossref
8.
Heen  AF , Lytvyn  L , Shapiro  M ,  et al.  Patient values and preferences on valve replacement for aortic stenosis: a systematic review.   Heart. 2021;107(16):1289-1295. doi:10.1136/heartjnl-2020-318334PubMedGoogle ScholarCrossref
9.
Zeng  L , Lytvyn  L , Wang  X ,  et al.  Values and preferences towards medical cannabis among people living with chronic pain: a mixed-methods systematic review.   BMJ Open. 2021;11(9):e050831. doi:10.1136/bmjopen-2021-050831PubMedGoogle ScholarCrossref
10.
Critical Appraisal Skills Programme. CASP qualitative studies checklist. Accessed December 13, 2022. https://casp-uk.net/casp-tools-checklists/
11.
Lewin  S , Bohren  M , Rashidian  A ,  et al.  Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 2: how to make an overall CERQual assessment of confidence and create a Summary of Qualitative Findings table.   Implement Sci. 2018;13(suppl 1):10. doi:10.1186/s13012-017-0689-2PubMedGoogle ScholarCrossref
12.
de Wijs  LEM , van Egmond  S , Devillers  ACA , Nijsten  T , Hijnen  D , Lugtenberg  M .  Needs and preferences of patients regarding atopic dermatitis care in the era of new therapeutic options: a qualitative study.   Arch Dermatol Res. 2022;1-9. doi:10.1007/s00403-021-02321-zPubMedGoogle ScholarCrossref
13.
Clement  C , Ridd  MJ , Roberts  K ,  et al.  Parents and GPs’ understandings and beliefs about food allergy testing in children with eczema: qualitative interview study within the Trial of Eczema allergy Screening Tests (TEST) feasibility trial.   BMJ Open. 2020;10(11):e041229. doi:10.1136/bmjopen-2020-041229PubMedGoogle ScholarCrossref
14.
Ameen  M , Meller  S , Pinter  A , Shear  NH , Soria  A ; (the BADEL Study Group).  Perception and experience of biologic therapy in atopic dermatitis: a qualitative focus group study of physicians and patients in Europe and Canada.   Dermatol Ther (Heidelb). 2021;11(6):2159-2177. doi:10.1007/s13555-021-00631-8PubMedGoogle ScholarCrossref
15.
Aubert-Wastiaux  H , Moret  L , Le Rhun  A ,  et al.  Topical corticosteroid phobia in atopic dermatitis: a study of its nature, origins and frequency.   Br J Dermatol. 2011;165(4):808-814. doi:10.1111/j.1365-2133.2011.10449.xPubMedGoogle ScholarCrossref
16.
Bazen  A , Sevagamoorthy  A , Barg  FK , Takeshita  J.   417 Adherence to topical therapy for atopic dermatitis: barriers and facilitators.   J Invest Dermatol. 2020;140(7):S54. doi:10.1016/j.jid.2020.03.425Google ScholarCrossref
17.
Boeri  M , Sutphin  J , Hauber  B , Cappelleri  JC , Romero  W , Di Bonaventura  M .  Quantifying patient preferences for systemic atopic dermatitis treatments using a discrete-choice experiment.   J Dermatolog Treat. 2022;33(3):1449-1458. doi:10.1080/09546634.2020.1832185PubMedGoogle ScholarCrossref
18.
Burkhart  CN , Burkhart  CG .  Pilot study of patient satisfaction with nonfluorinated topical steroids compared with a topical immunomodulator in atopiform dermatitis.   Int J Dermatol. 2004;43(3):215-219. doi:10.1111/j.1365-4632.2004.02118.xPubMedGoogle ScholarCrossref
19.
Cadmus  SD , Sebastian  KR , Warren  D ,  et al.  Efficacy and patient opinion of wet-wrap dressings using 0.1% triamcinolone acetonide ointment vs cream in the treatment of pediatric atopic dermatitis: a randomized split-body control study.   Pediatr Dermatol. 2019;36(4):437-441. doi:10.1111/pde.13830PubMedGoogle ScholarCrossref
20.
Capozza  K , Schwartz  A .  Does it work and is it safe: parents’ perspectives on adherence to medication for atopic dermatitis.   Pediatr Dermatol. 2020;37(1):58-61. doi:10.1111/pde.13991PubMedGoogle ScholarCrossref
21.
Charman  CR , Morris  AD , Williams  HC .  Topical corticosteroid phobia in patients with atopic eczema.   Br J Dermatol. 2000;142(5):931-936. doi:10.1046/j.1365-2133.2000.03473.xPubMedGoogle ScholarCrossref
22.
Djokic-Gallagher  J , Rosher  P , Oliveira  G , Walker  J .  A double-blind, randomised study comparing the skin hydration and acceptability of two emollient products in atopic eczema patients with dry skin.   Dermatol Ther (Heidelb). 2017;7(3):397-406. doi:10.1007/s13555-017-0188-zPubMedGoogle ScholarCrossref
23.
Draelos  ZD .  A clinical evaluation of the comparable efficacy of hyaluronic acid-based foam and ceramide-containing emulsion cream in the treatment of mild-to-moderate atopic dermatitis.   J Cosmet Dermatol. 2011;10(3):185-188. doi:10.1111/j.1473-2165.2011.00568.xPubMedGoogle ScholarCrossref
24.
Ervin  C , Crawford  R , Evans  E ,  et al.  Patient and caregiver preferences on treatment attributes for atopic dermatitis.   J Dermatolog Treat. 2022;33(4):2225-2233. doi:10.1080/09546634.2021.1940810PubMedGoogle ScholarCrossref
25.
Fenerty  SD , O’Neill  JL , Gustafson  CJ , Feldman  SR .  Maternal adherence factors in the treatment of pediatric atopic dermatitis.   JAMA Dermatol. 2013;149(2):229-231. doi:10.1001/2013.jamadermatol.253PubMedGoogle ScholarCrossref
26.
Fukaya  M .  Why do patients with atopic dermatitis refuse to apply topical corticosteroids?   Dermatology. 2000;201(3):242-245. doi:10.1159/000018495PubMedGoogle ScholarCrossref
27.
Gerner  T , Haugaard  JH , Vestergaard  C ,  et al.  Healthcare utilization in Danish children with atopic dermatitis and parental topical corticosteroid phobia.   Pediatr Allergy Immunol. 2021;32(2):331-341. doi:10.1111/pai.13394PubMedGoogle ScholarCrossref
28.
Ghio  D , Muller  I , Greenwell  K ,  et al.  ‘It’s like the bad guy in a movie who just doesn’t die:’ a qualitative exploration of young people’s adaptation to eczema and implications for self-care.   Br J Dermatol. 2020;182(1):112-118. doi:10.1111/bjd.18046PubMedGoogle ScholarCrossref
29.
Gollnick  H , Luger  T , Freytag  S , Bräutigam  M ; STABIEL study group.  StabiEL: stabilization of skin condition with Elidel—a patients’ satisfaction observational study addressing the treatment, with pimecrolimus cream, of atopic dermatitis pretreated with topical corticosteroid.   J Eur Acad Dermatol Venereol. 2008;22(11):1319-1325. doi:10.1111/j.1468-3083.2008.02807.xPubMedGoogle ScholarCrossref
30.
Gore  C , Johnson  RJ , Caress  AL , Woodcock  A , Custovic  A .  The information needs and preferred roles in treatment decision-making of parents caring for infants with atopic dermatitis: a qualitative study.   Allergy. 2005;60(7):938-943. doi:10.1111/j.1398-9995.2005.00776.xPubMedGoogle ScholarCrossref
31.
Greenwell  K , Ghio  D , Muller  I ,  et al.  Taking charge of eczema self-management: a qualitative interview study with young people with eczema.   BMJ Open. 2021;11(1):e044005. doi:10.1136/bmjopen-2020-044005PubMedGoogle ScholarCrossref
32.
Hon  KLE , Kam  WYC , Leung  TF ,  et al.  Steroid fears in children with eczema.   Acta Paediatr. 2006;95(11):1451-1455. doi:10.1080/08035250600612298PubMedGoogle ScholarCrossref
33.
Hon  KLE , Wang  SS , Pong  NH , Leung  TF .  The ideal moisturizer: a survey of parental expectations and practice in childhood-onset eczema.   J Dermatolog Treat. 2013;24(1):7-12. doi:10.3109/09546634.2012.672713PubMedGoogle ScholarCrossref
34.
Howells  LM , Chalmers  JR , Cowdell  F , Ratib  S , Santer  M , Thomas  KS .  ‘When it goes back to my normal I suppose’: a qualitative study using online focus groups to explore perceptions of ‘control’ among people with eczema and parents of children with eczema in the UK.   BMJ Open. 2017;7(11):e017731. doi:10.1136/bmjopen-2017-017731PubMedGoogle ScholarCrossref
35.
Howells  L , Thomas  KS , Sears  AV ,  et al; Long-term control of eczema working group for the HOME initiative.  Defining and measuring ‘eczema control’: an international qualitative study to explore the views of those living with and treating atopic eczema.   J Eur Acad Dermatol Venereol. 2019;33(6):1124-1132. doi:10.1111/jdv.15475PubMedGoogle ScholarCrossref
36.
Joergensen  KM , Jemec  GBE .  Use of moisturizers among Danish atopic dermatitis patients—which perceived product characteristics associate with long-term adherence?   J Dermatolog Treat. 2018;29(2):116-122. doi:10.1080/09546634.2017.1358803PubMedGoogle ScholarCrossref
37.
Johnson  MC , Heron  CE , Feldman  SR .  Caregiver preferences for the treatment of childhood atopic dermatitis.   J Cutan Med Surg. 2021;25(3):336-338. doi:10.1177/1203475420988866PubMedGoogle ScholarCrossref
38.
Johnston  GA , Bilbao  RM , Graham-Brown  RA .  The use of complementary medicine in children with atopic dermatitis in secondary care in Leicester.   Br J Dermatol. 2003;149(3):566-571. doi:10.1046/j.1365-2133.2003.05471.xPubMedGoogle ScholarCrossref
39.
Jung  HJ , Bae  JY , Kim  JE ,  et al.  Survey of disease awareness, treatment behavior and treatment satisfaction in patients with atopic dermatitis in Korea: a multicenter study.   J Dermatol. 2018;45(10):1172-1180. doi:10.1111/1346-8138.14540PubMedGoogle ScholarCrossref
40.
Kamei  K , Hirose  T , Yoshii  N , Tanaka  A .  Burden of illness, medication adherence, and unmet medical needs in Japanese patients with atopic dermatitis: a retrospective analysis of a cross-sectional questionnaire survey.   J Dermatol. 2021;48(10):1491-1498. doi:10.1111/1346-8138.16054PubMedGoogle ScholarCrossref
41.
Kosse  RC , Bouvy  ML , Daanen  M , de Vries  TW , Koster  ES .  Adolescents’ perspectives on atopic dermatitis treatment-experiences, preferences, and beliefs.   JAMA Dermatol. 2018;154(7):824-827. doi:10.1001/jamadermatol.2018.1096PubMedGoogle ScholarCrossref
42.
Koster  ES , Philbert  D , Wagelaar  KR , Galle  S , Bouvy  ML .  Optimizing pharmaceutical care for pediatric patients with dermatitis: perspectives of parents and pharmacy staff.   Int J Clin Pharm. 2019;41(3):711-718. doi:10.1007/s11096-019-00827-1PubMedGoogle ScholarCrossref
43.
Kunkiel  K , Natkańska  A , Nędzi  M , Zawadzka-Krajewska  A , Feleszko  W .  Patients’ preferences of leave-on emollients: a survey on patients with atopic dermatitis.   J Dermatolog Treat. 2022;33(2):1143-1145. doi:10.1080/09546634.2020.1772452PubMedGoogle ScholarCrossref
44.
Kurtti  A , Jagdeo  J .  Analysis of Reddit reveals atopic dermatitis patient questions.   J Drugs Dermatol. 2021;20(6):653-658. doi:10.36849/JDD.2021.5734PubMedGoogle Scholar
45.
Lee  JY , Her  Y , Kim  CW , Kim  SS .  Topical corticosteroid phobia among parents of children with atopic eczema in Korea.   Ann Dermatol. 2015;27(5):499-506. doi:10.5021/ad.2015.27.5.499PubMedGoogle ScholarCrossref
46.
Rhun  AL , Wastiaux  HA , Moret  L ,  et al.  Fears regarding the use of topical corticosteroids in atopic dermatitis: looking at the coping strategies and the role of health care providers: a qualitative study.   Educ Ther Patient/ Ther Patient Educ. 2015;7(2):20102. doi:10.1051/tpe/2015011Google ScholarCrossref
47.
Li  Y , Han  T , Li  W , Li  Y , Guo  X , Zheng  L .  Awareness of and phobias about topical corticosteroids in parents of infants with eczema in Hangzhou, China.   Pediatr Dermatol. 2018;35(4):463-467. doi:10.1111/pde.13527PubMedGoogle ScholarCrossref
48.
Lundin  S , Jonsson  M , Wahlgren  C , Johansson  E , Bergstrom  A , Kull  I .  “You try to take as little as possible”—a qualitative study of young adults with eczema recruited from the population-based birth cohort (BAMSE).   Allergy. 2019;74(S106):130-331. https://www.webofscience.com/wos/woscc/full-record/WOS:000480254002112?SID=USW2EC0EFF9UkbYlFp5q8fIR4zfbTGoogle Scholar
49.
Lundin  S , Jonsson  M , Wahlgren  CF , Johansson  E , Bergstrom  A , Kull  I .  Young adults’ perceptions of living with atopic dermatitis in relation to the concept of self-management: a qualitative study.   BMJ Open. 2021;11(6):e044777. doi:10.1136/bmjopen-2020-044777PubMedGoogle ScholarCrossref
50.
Maghen  P , Unrue  EL , Oussedik  E , Cline  A , Cardwell  LA , Feldman  SR .  Regardless of how risks are framed, patients seem hesitant to use topical steroids for atopic dermatitis.   Br J Dermatol. 2019;181(4):842-844. doi:10.1111/bjd.17929PubMedGoogle ScholarCrossref
51.
McAlister  RO , Tofte  SJ , Doyle  JJ , Jackson  A , Hanifin  JM .  Patient and physician perspectives vary on atopic dermatitis.   Cutis. 2002;69(6):461-466.PubMedGoogle Scholar
52.
Noerreslet  M , Jemec  GBE , Traulsen  JM .  Involuntary autonomy: patients’ perceptions of physicians, conventional medicines and risks in the management of atopic dermatitis.   Soc Sci Med. 2009;69(9):1409-1415. doi:10.1016/j.socscimed.2009.08.036PubMedGoogle ScholarCrossref
53.
Nørreslet  M , Bissell  P , Traulsen  JM .  From consumerism to active dependence: patterns of medicines use and treatment decisions among patients with atopic dermatitis.   Health (London). 2010;14(1):91-106. doi:10.1177/1363459309347648PubMedGoogle ScholarCrossref
54.
O’Connor  C , Dhonncha  EN , Murphy  M .  “His first word was ‘cream’:” the burden of treatment in pediatric atopic dermatitis—a mixed methods study.   Dermatol Ther. 2022;35(3):e15273. doi:10.1111/dth.15273PubMedGoogle ScholarCrossref
55.
Onumah  N , Kircik  L .  Pimecrolimus cream and tacrolimus ointment in the treatment of atopic dermatitis: a pilot study on patient preference.   J Drugs Dermatol. 2013;12(10):1145-1148.PubMedGoogle Scholar
56.
Okubo  Y , Ho  KA , Fifer  S , Fujita  H , Oki  Y , Taguchi  Y .  Patient and physician preferences for atopic dermatitis injection treatments in Japan.   J Dermatolog Treat. 2020;31(8):821-830. doi:10.1080/09546634.2019.1623860PubMedGoogle ScholarCrossref
57.
Paller  AS , McAlister  RO , Doyle  JJ , Jackson  A .  Perceptions of physicians and pediatric patients about atopic dermatitis, its impact, and its treatment.   Clin Pediatr (Phila). 2002;41(5):323-332. doi:10.1177/000992280204100505PubMedGoogle ScholarCrossref
58.
Powell  K , Le Roux  E , Banks  J , Ridd  MJ .  GP and parent dissonance about the assessment and treatment of childhood eczema in primary care: a qualitative study.   BMJ Open. 2018;8(2):e019633. doi:10.1136/bmjopen-2017-019633PubMedGoogle ScholarCrossref
59.
Retzler  J , Smith  A , Reaney  M , Rout  R , Hudson  R .  Process utilities for topical treatment in atopic dermatitis.   Qual Life Res. 2019;28(9):2373-2381. doi:10.1007/s11136-019-02174-0PubMedGoogle ScholarCrossref
60.
Roh  NK , Han  SH , Kim  MJ ,  et al.  Awareness of atopic dermatitis and attitudes toward different types of medical institutions for its treatment among adult patients and the parents of pediatric patients: a survey of 500 participants.   Ann Dermatol. 2016;28(6):725-732. doi:10.5021/ad.2016.28.6.725PubMedGoogle ScholarCrossref
61.
Santer  M , Muller  I , Yardley  L , Lewis-Jones  S , Ersser  S , Little  P .  Parents’ and carers’ views about emollients for childhood eczema: qualitative interview study.   BMJ Open. 2016;6(8):e011887. doi:10.1136/bmjopen-2016-011887PubMedGoogle ScholarCrossref
62.
Santer  M , Burgess  H , Yardley  L ,  et al.  Experiences of carers managing childhood eczema and their views on its treatment: a qualitative study.   Br J Gen Pract. 2012;62(597):e261-e267. doi:10.3399/bjgp12X636083PubMedGoogle ScholarCrossref
63.
Santer  M , Burgess  H , Yardley  L ,  et al.  Managing childhood eczema: qualitative study exploring carers’ experiences of barriers and facilitators to treatment adherence.   J Adv Nurs. 2013;69(11):2493-2501. doi:10.1111/jan.12133PubMedGoogle ScholarCrossref
64.
Schmitt  J , Csötönyi  F , Bauer  A , Meurer  M .  Determinants of treatment goals and satisfaction of patients with atopic eczema.   J Dtsch Dermatol Ges. 2008;6(6):458-465. doi:10.1111/j.1610-0387.2007.06609.xPubMedGoogle ScholarCrossref
65.
Smith  SD , Hong  E , Fearns  S , Blaszczynski  A , Fischer  G .  Corticosteroid phobia and other confounders in the treatment of childhood atopic dermatitis explored using parent focus groups.   Australas J Dermatol. 2010;51(3):168-174. doi:10.1111/j.1440-0960.2010.00636.xPubMedGoogle ScholarCrossref
66.
Steinke  S , Langenbruch  A , Ständer  S , Franzke  N , Augustin  M .  Therapeutic benefits in atopic dermatitis care from the patients’ perspective: results of the German national health care study ‘Atopic Health’.   Dermatology. 2014;228(4):350-359. doi:10.1159/000358587PubMedGoogle ScholarCrossref
67.
Teasdale  EJ , Muller  I , Santer  M .  Carers’ views of topical corticosteroid use in childhood eczema: a qualitative study of online discussion forums.   Br J Dermatol. 2017;176(6):1500-1507. doi:10.1111/bjd.15130PubMedGoogle ScholarCrossref
68.
Thomas  C , Raibouaa  A , Wollenberg  A ,  et al.  PMU105 Patient preferences for systemic atopic dermatitis treatments in the UK, France and Spain: a discrete choice experiment.   Value Health. 2020;23:S621. doi:10.1016/j.jval.2020.08.1317Google ScholarCrossref
69.
Torrelo  A , Ortiz  J , Alomar  A , Ros  S , Prieto  M , Cuervo  J .  Atopic dermatitis: impact on quality of life and patients’ attitudes toward its management.   Eur J Dermatol. 2012;22(1):97-105. doi:10.1684/ejd.2011.1560PubMedGoogle ScholarCrossref
70.
Veenje  S , Osinga  H , Antonescu  I , Bos  B , de Vries  TW .  Focus group parental opinions regarding treatment with topical corticosteroids on children with atopic dermatitis.   Allergol Immunopathol (Madr). 2019;47(2):166-171. doi:10.1016/j.aller.2018.05.007PubMedGoogle ScholarCrossref
71.
Wilson  F , Harnik  E , Gore  C .  1745 Exploring parental understanding and views on topical corticosteroids (TCS) and TCS labelling in paediatric atopic dermatitis.   Allergy. 2020;75(S109):568-610.Google Scholar
72.
Zuberbier  T , Orlow  SJ , Paller  AS ,  et al.  Patient perspectives on the management of atopic dermatitis.   J Allergy Clin Immunol. 2006;118(1):226-232. doi:10.1016/j.jaci.2006.02.031PubMedGoogle ScholarCrossref
73.
Zeichner  J , Feldman  S , Ervin  C , Crawford  R , Evans  E , Zielinski  M .  26652 Patient and caregiver perspectives on treatment attributes for atopic dermatitis.   J Am Acad Dermatol. 2021;85(3):AB111. doi:10.1016/j.jaad.2021.06.461Google ScholarCrossref
74.
Augustin  M , Langenbruch  A , Blome  C ,  et al.  Characterizing treatment-related patient needs in atopic eczema: insights for personalized goal orientation.   J Eur Acad Dermatol Venereol. 2020;34(1):142-152. doi:10.1111/jdv.15919PubMedGoogle ScholarCrossref
75.
Xie  F , Zhou  T .  Industry sponsorship bias in cost effectiveness analysis: registry based analysis.   BMJ. 2022;377:e069573. doi:10.1136/bmj-2021-069573PubMedGoogle ScholarCrossref
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
Want full access to the AMA Ed Hub?
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Close
Close

Lookup An Activity

or

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close