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Palpitations and Shortness of Breath—Just a “Bump in the Road” or Something More?

To identify the key insights or developments described in this article
1 Credit CME

A previously healthy person in their 60s with progressive shortness of breath and fatigue for the past 6 months presented to the emergency department with palpitations and shortness of breath. The patient’s simultaneously recorded 3-lead rhythm electrocardiogram (ECG) on presentation is shown in the Figure, A, and results of a 12-lead ECG after receiving intravenous amiodarone are shown in Figure, B.

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A previously healthy person in their 60s with progressive shortness of breath and fatigue for the past 6 months presented to the emergency department with palpitations and shortness of breath. The patient’s simultaneously recorded 3-lead rhythm electrocardiogram (ECG) on presentation is shown in the Figure, A, and results of a 12-lead ECG after receiving intravenous amiodarone are shown in Figure, B.

Questions: How would you interpret the initial rhythm strip and 12-lead ECG findings recorded after receiving amiodarone?

The initial 3-lead rhythm ECG revealed salvos of wide QRS complex tachycardia that terminated spontaneously and were separated by several sinus rhythm beats. The sixth and fifteenth QRS complexes were fusion complexes with an intermediate morphology between the sinus conducted QRS complex (fifth and sixteenth QRS) and the wide QRS complex tachycardia (best appreciated in leads V1 and V5) (Figure, A). The fusion complexes confirmed that the wide QRS complex salvos represent ventricular tachycardia (VT). Retrograde P waves can be observed in lead V1 in the ST-T waves after the first to fourth and the eighth to twelfth QRS complexes by comparing them to the ST-T waves after the seventh QRS complex. The wide QRS complex tachycardias terminated with retrograde P waves after the fourth and twelfth QRS complexes. This finding confirmed VT with retrograde conduction because in atrial tachycardia with aberrant conduction atrial activity drives ventricular activity and the tachycardia will thus terminate with a QRS complex.

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Article Information

Corresponding Author: Nikita Jhawar, MD, Department of Internal Medicine, Mayo Clinic, 4500 San Pablo Ave, Jacksonville, FL 32224 (jhawar.nikita@mayo.edu).

Published Online: February 6, 2023. doi:10.1001/jamainternmed.2022.6359

Conflict of Interest Disclosures: None reported.

Disclaimer: Dr Goldschlager is Challenges in Electrocardiography Section Editor of JAMA Internal Medicine, but she was not involved in any of the decisions regarding review of the manuscript or its acceptance.

References
1.
Kusumoto  F , Interpretation  ECG .  From Pathophysiology to Clinical Application. 2nd ed. Springer Nature Switzerland; 2020.
2.
Fontaine  G , Frank  R , Bonnet  M , Cabrol  C , Guiraudon  G .  [Experimental and clinical study of Wolff-Parkinson-White and myocardial ischemia syndromes by cartography of epicardial ventricular depolarization].   Coeur Med Interne. 1973;12(1):105-113.PubMedGoogle Scholar
3.
Pérez-Riera  AR , Barbosa-Barros  R , Daminello-Raimundo  R ,  et al.  Epsilon wave: a review of historical aspects.   Indian Pacing Electrophysiol J. 2019;19(2):63-67.PubMedGoogle ScholarCrossref
4.
Marcus  FI , McKenna  WJ , Sherrill  D ,  et al.  Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria.   Circulation. 2010;121(13):1533-1541.PubMedGoogle ScholarCrossref
5.
Corrado  D , Perazzolo Marra  M , Zorzi  A ,  et al.  Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria.   Int J Cardiol. 2020;319:106-114.PubMedGoogle ScholarCrossref
6.
Mills  KJ , Ferrer  MS , Gonzalez  MD .  Prominent epsilon waves in a patient with cardiac sarcoidosis.   JACC Case Rep. 2020;2(4):577-582.PubMedGoogle ScholarCrossref
7.
Rosenfeld  LE , Chung  MK , Harding  CV ,  et al.  Arrhythmias in cardiac sarcoidosis bench to bedside: a case-based review.   Circ Arrhythm Electrophysiol. 2021;14(2):e009203.PubMedGoogle Scholar
8.
Birnie  DH , Sauer  WH , Bogun  F ,  et al.  HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis.   Heart Rhythm. 2014;11(7):1305-1323.PubMedGoogle ScholarCrossref
9.
Nordenswan  HK , Lehtonen  J , Ekström  K ,  et al.  Outcome of cardiac sarcoidosis presenting with high-grade atrioventricular block.   Circ Arrhythm Electrophysiol. 2018;11(8):e006145.PubMedGoogle Scholar
10.
Nordenswan  HK , Pöyhönen  P , Lehtonen  J ,  et al.  Incidence of sudden cardiac death and life-threatening arrhythmias in clinically manifest cardiac sarcoidosis with and without current indications for an implantable cardioverter defibrillator.   Circulation. 2022;146(13):964-975.PubMedGoogle ScholarCrossref
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