A man in his 20s with obesity (body mass index, 31.2 [calculated as weight in kilograms divided by height in meters squared]) presented with numerous asymptomatic, reddish-yellow papules on his back and extensor surfaces of the extremities that suddenly developed 2 years earlier. He consumed a high-fat diet with a history of poorly controlled diabetes and denied a family history of dyslipidemia, metabolic syndrome, vascular disease, pancreatitis, or cutaneous diseases. On physical examination, numerous dome-shaped, firm, yellow papules were present symmetrically on the back, shoulder, arm, thigh, and knees (Figure, A). Laboratory examinations showed elevated levels of triglycerides (6697 mg/dL) and total cholesterol (943 mg/dL) and a decreased level of high-density lipoprotein (0.016 mg/dL). Histopathological examination showed large, pale-staining, lipid-laden histiocytes (foamy cells) and obvious loose lipids in the upper dermis (Figure, B) that were consistent with an eruptive xanthoma.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Corresponding Author: Jun Li, MD, Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, China (email@example.com).
Published Online: March 1, 2023. doi:10.1001/jamadermatol.2022.5834
Conflict of Interest Disclosures: None were reported.
Additional Contributions: We thank the patient for granting permission to publish this information.
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