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Managing Facial Hyperpigmentation

To identify the key insights or developments described in this article
1 Credit CME

Hyperpigmentation is a common cutaneous concern in individuals with skin of color,1 often leading to psychosocial distress.2 Given the lack of rigorous clinical studies, expert opinion guides accepted treatment algorithms. Acquired facial hyperpigmentation commonly presents as melasma or postinflammatory hyperpigmentation (PIH).

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Roopal V. Kundu, MD, Department of Dermatology, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Ste 1600, Chicago, IL 60611 (roopal.kundu@nm.org).

Published Online: June 7, 2023. doi:10.1001/jamadermatol.2023.1414

Conflict of Interest Disclosures: Dr Kundu reported personal fees (royalties) from UpToDate outside the submitted work. Dr Riley reported personal fees from Novartis Pharmaceuticals outside the submitted work. No other disclosures were reported.

References
1.
Davis  SA , Narahari  S , Feldman  SR , Huang  W , Pichardo-Geisinger  RO , McMichael  AJ .  Top dermatologic conditions in patients of color: an analysis of nationally representative data.   J Drugs Dermatol. 2012;11(4):466-473.PubMedGoogle Scholar
2.
Maymone  MBC , Neamah  HH , Wirya  SA ,  et al.  The impact of skin hyperpigmentation and hyperchromia on quality of life: a cross-sectional study.   J Am Acad Dermatol. 2017;77(4):775-778. doi:10.1016/j.jaad.2017.05.009PubMedGoogle ScholarCrossref
3.
Lyons  AB , Trullas  C , Kohli  I , Hamzavi  IH , Lim  HW .  Photoprotection beyond ultraviolet radiation: a review of tinted sunscreens.   J Am Acad Dermatol. 2021;84(5):1393-1397. doi:10.1016/j.jaad.2020.04.079PubMedGoogle ScholarCrossref
4.
Mahmoud  BH , Ruvolo  E , Hexsel  CL ,  et al.  Impact of long-wavelength UVA and visible light on melanocompetent skin.   J Invest Dermatol. 2010;130(8):2092-2097. doi:10.1038/jid.2010.95PubMedGoogle ScholarCrossref
5.
Tse  TW .  Hydroquinone for skin lightening: safety profile, duration of use and when should we stop?   J Dermatolog Treat. 2010;21(5):272-275. doi:10.3109/09546630903341945PubMedGoogle ScholarCrossref
6.
Ferreira Cestari  T , Hassun  K , Sittart  A , de Lourdes Viegas  M .  A comparison of triple combination cream and hydroquinone 4% cream for the treatment of moderate to severe facial melasma.   J Cosmet Dermatol. 2007;6(1):36-39. doi:10.1111/j.1473-2165.2007.00288.xPubMedGoogle ScholarCrossref
7.
Austin  E , Nguyen  JK , Jagdeo  J .  Topical treatments for melasma: a systematic review of randomized controlled trials.   J Drugs Dermatol. 2019;18(11):S1545961619P1156X.PubMedGoogle Scholar
8.
Kim  KM , Lim  HW .  The uses of tranexamic acid in dermatology: a review.   Int J Dermatol. 2023;62(5):589-598. doi:10.1111/ijd.16160PubMedGoogle ScholarCrossref
9.
Bailey  AJM , Li  HO , Tan  MG , Cheng  W , Dover  JS .  Microneedling as an adjuvant to topical therapies for melasma: a systematic review and meta-analysis.   J Am Acad Dermatol. 2022;86(4):797-810. doi:10.1016/j.jaad.2021.03.116PubMedGoogle ScholarCrossref
10.
Lai  D , Zhou  S , Cheng  S , Liu  H , Cui  Y .  Laser therapy in the treatment of melasma: a systematic review and meta-analysis.   Lasers Med Sci. 2022;37(4):2099-2110. doi:10.1007/s10103-022-03514-2PubMedGoogle ScholarCrossref
AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 credit toward the CME [and Self-Assessment requirements] of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

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