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Gynecology

Nonhormonal Therapies for Menopausal Vasomotor Symptoms

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1 Credit CME

JAMA

Published Online: September 15, 2023

JAMA Insights

Article Information and Disclosures

Jacob P. Christ, MD¹;

Víctor M. Navarro, PhD^2,3;

Susan D. Reed, MD, MPH, MS⁴

Author Affiliations

¹Department of Obstetrics and Gynecology, University of San Francisco, San Francisco, California
²Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts
³Harvard Graduate Program in Neuroscience, Boston, Massachusetts
⁴Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle

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Vasomotor symptoms, which include night sweats and hot flashes, are the defining symptoms of the menopause transition and early postmenopause. Vasomotor symptoms result in diminished quality of life and affect work satisfaction, productivity, mood, and sleep. Prospective cohort studies show that vasomotor symptoms persist for 7 to 10 years in most individuals and even longer in at least 10%.¹ On average, people experience 4 to 5 vasomotor symptoms daily, but some may experience as many as 20. Vasomotor symptoms are one of the primary menopause-related problems for which patients seek medical treatment.²

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Article Information

Corresponding Author: Susan D. Reed, MD, MPH, MS, Department of Obstetrics and Gynecology, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195 (reeds@uw.edu).

Published Online: September 15, 2023. doi:10.1001/jama.2023.15965

Conflict of Interest Disclosures: Dr Christ reported grants from Pacific Coast Reproductive Society and other (free devices for research) from Dexcom outside the submitted work. Dr Navarro reported grants from the National Institutes of Health (Eunice Kennedy Shriver National Institute of Child Health and Human Development) and personal fees from Bayer (consultancy services) outside the submitted work. Dr Reed reported grants from the National Institutes of Health and Bayer outside the submitted work; royalties from UpToDate; and a patent issued for methods and compositions for treating vasomotor symptoms (No. 11 083 726).

Additional Contributions: We greatly appreciate the illustration created by Peter J. Christ, BFA, MA, Peterjacobchrist, LLC; and the administrative assistance of Nicole Wothe, BS, University of Washington. Neither individual received compensation in association with their contributions to this article.

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 credit toward the CME [and Self-Assessment requirements] of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.