NAFLD is characterized by hepatic steatosis associated with metabolic abnormalities such as insulin resistance, dyslipidemia, obesity, and hypertension. Prevalence of NAFLD in US adults approaches 40%, with high-risk fibrosis more than doubling between 2000 and 2016 (National Health and Nutrition Examination Survey).1 Less than 5% of patients with NAFLD are aware of their condition, and 12% to 14% also have NASH, which can progress to advanced fibrosis, cirrhosis, and hepatocellular carcinoma. Diagnostic screening and initial treatment for NAFLD can often be carried out in primary care settings.2
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Corresponding Author: Peggy B. Leung, MD, Weill Cornell Medicine, 505 E 70th St, HT-4, New York, NY 10021 (email@example.com).
Published Online: October 16, 2023. doi:10.1001/jama.2023.17935
Conflict of Interest Disclosures: Dr Kumar reported receiving personal fees from Intercept, Gilead, Ipsen, and Novo Nordisk. No other disclosures were reported.
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