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Repeatedly Malignant ST-Segment Elevation

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1 Credit CME

A male patient in their early 50s with no history of prior known diseases was admitted to the hepatobiliary surgery unit with epigastric pain and jaundice of 2 weeks. Electrocardiogram (ECG) findings at admission were normal. On the third day of admission, the patient experienced a sudden squeezing pain in the anterior chest at rest, with a heart rate of 44 beats/min, blood pressure of 97/60 mm Hg, and oxygen saturation of 98%. The ECG (Figure, A) showed troponin I level of 0.107 ng/mL (normal reference value, 0 to approximately 0.034 ng/mL; to convert to micrograms per liter, multiply by 1). Isoproterenol was immediately administered by intravenous infusion due to a significantly decreased heart rate. About 20 minutes later, the patient reported that the pain was relieved, and a repeat ECG was done (Figure, B).

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A male patient in their early 50s with no history of prior known diseases was admitted to the hepatobiliary surgery unit with epigastric pain and jaundice of 2 weeks. Electrocardiogram (ECG) findings at admission were normal. On the third day of admission, the patient experienced a sudden squeezing pain in the anterior chest at rest, with a heart rate of 44 beats/min, blood pressure of 97/60 mm Hg, and oxygen saturation of 98%. The ECG (Figure, A) showed troponin I level of 0.107 ng/mL (normal reference value, 0 to approximately 0.034 ng/mL; to convert to micrograms per liter, multiply by 1). Isoproterenol was immediately administered by intravenous infusion due to a significantly decreased heart rate. About 20 minutes later, the patient reported that the pain was relieved, and a repeat ECG was done (Figure, B).

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Article Information

Corresponding Author: Yi Tang, PhD, Department of Cardiology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha 410005, China (da123zhiruoyu@163.com).

Published Online: November 20, 2023. doi:10.1001/jamainternmed.2023.4841

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank Xiaohui Duan, PhD, from Hunan Provincial People’s Hospital for providing part data of the patient; compensation was not received.

References
1.
Trukhan  DI , Degovtsov  EN , Davydov  EL .  Cholecystocardial syndrome in real clinical practice.   Meditsinskiy Sovet. 2021;(4):212-219. doi:10.21518/2079-701X-2021-4-212-219Google ScholarCrossref
2.
Vetshev  PS , Sulimov  VA , Nogtev  PV .  Cholecystocardial syndrome in clinical practice.   Hepatology. 2004;(6):15-19.Google Scholar
3.
Babcock  RH .  Chronic cholecystitis as a cause of myocardial incompetence: report of thirteen cases.   JAMA. 1909;LII(24):1904-1911. doi:10.1001/jama.1909.25420500006002Google ScholarCrossref
4.
Kaufman  JM , Lubera  R .  Preoperative use of atropine and electrocardiographic changes: differentiation of ischemic from biliary-induced abnormalities.   JAMA. 1967;200(3):197-200. doi:10.1001/jama.1967.03120160063006PubMedGoogle ScholarCrossref
5.
Xiaoping  W .  Biliary heart syndrome.   Zhongguo Shiyong Neike Zazhi. 2007;(08):574-575.Google Scholar
6.
Fitz-Hugh  T , Wolferth  CC .  Cardiac improvement following gall-bladder surgery: electrocardiographic evidence in cases with associated myocardial disease.   Ann Surg. 1935;101(1):478-483. doi:10.1097/00000658-193501000-00051PubMedGoogle ScholarCrossref
7.
Hampton  AG , Beckwith  JR , Wood  JE  Jr .  The relationship between heart disease and gall-bladder disease.   Ann Intern Med. 1959;50(5):1135-1148. doi:10.7326/0003-4819-50-5-1135PubMedGoogle ScholarCrossref
AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 credit toward the CME of the American Board of Surgery’s Continuous Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

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