Stimulation Session in Patient 12 Showing Hypotensive Responses Induced by Brodmann Area 25 Stimulation

The patient has essential hypertension and is receiving treatment. Shown is monopolar stimulation of Brodmann area 25 (electrode FA1 [reference electrode AI2]) in patient 12 with simultaneous recording of (from top of machine display to bottom) systolic, diastolic, and mean arterial pressure and heart rate. Stimulation periods are clearly seen in the electroencephalogram record, as evidenced by electrical artifact. Stimulation 1, Before stimulation begins, systolic arterial pressure is stable (148-150 beats/min). Seven seconds after stimulation begins at current intensity of 5 mA, systolic arterial pressure decreases progressively during stimulation and continues for 10 seconds after stimulation is discontinued, from 148 to 128 mm Hg. Then, systolic arterial pressure progressively increases and remains stable at 144 to 145 mm Hg. Stimulation 2, Stimulation at 6 mA of intensity. Systolic arterial pressure progressively decreases after 8 seconds for the entire stimulation period and for 20 seconds after stimulation is discontinued. Stimulation 3, Once systolic arterial pressure stabilizes, stimulation starts at 7 mA. After 7 seconds, systolic arterial pressure progressively decreases from 145 to 116 mm Hg and for 12 seconds after stimulation is discontinued. Systolic arterial pressure then increases back up to 138 mm Hg.