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Fluorescence adaptive optics scanning light ophthalmoscopy (AOSLO) can provide in vivo autofluorescence images with microscopic resolution to elucidate the cellular origin of abnormalities in Stargardt disease type 1. This video shows a comparison of autofluorescence and reflectance images from the same retinal location and demonstrates an abnormal autofluorescence structure more consistent in appearance with photoreceptor than retinal pigment epithelial cell reflectance, suggesting that photoreceptor damage mediated by the accumulation of lipofuscin precursors may precede retinal pigment epithelial cell death in Stargardt disease type 1.
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