Time-lapse Magnetic Resonance Imaging (MRI) From a Patient With Multiple Sclerosis (MS) Showing an Expanding Rim+ and a Shrinking Rim− Lesion

This time-lapse video, constructed from 118 coregistered intensity-normalized MRI scans (proton density [PD] sequence) obtained over 29 years (average, 4 scans per year) from a man with relapsing MS, shows examples of an expanding (red box) and a shrinking (blue box) lesion. The expanding lesion had a paramagnetic rim at 7T MRI. The video also shows static MRI images (both PD and postcontrast T1-weighted images) for the expanding lesion every 5 years.