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This time-lapse video, constructed from 118 coregistered intensity-normalized MRI scans (proton density [PD] sequence) obtained over 29 years (average, 4 scans per year) from a man with relapsing MS, shows examples of an expanding (red box) and a shrinking (blue box) lesion. The expanding lesion had a paramagnetic rim at 7T MRI. The video also shows static MRI images (both PD and postcontrast T1-weighted images) for the expanding lesion every 5 years.
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