Relative Glucose Metabolism on Fluorine 18–Labeled Fluorodeoxyglucose Positron Emission Tomographic (PET) Imaging in PreSxC9 Participants vs Controls

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) may share a monogenetic cause in the form of hexanucleotide repeat expansions in the 3′ untranslated region of the chromosome 9 open reading frame 72 gene (). This video demonstrates relative glucose hypometabolism in frontotemporal regions of a presymptomatic carrier (preSxC9) on [18F]FDG PET imaging, raising the prospect that PET imaging may be a biomarker for early ALS and/or FTD in some patients. Click the Related Article link for complete details.