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Calcinosis cutis is calcium deposition in the skin caused by tissue damage, abnormal calcium metabolism, or unknown reasons. It typically manifests as skin nodules, hardening with limitations of mobility, and skin ulceration in the lower extremities. Graft-versus-host disease, where the immune system activates to defend the body against a stem cell or other transplant, is a newly recognized cause. This video animates a 3-dimensional reconstruction of computed tomography images in a patient with calcinosis cutis caused by graft-versus-host disease, showing extensive soft tissue calcification beneath and surrounding skin ulceration. Click the Related Article link for complete clinical information.
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