Intraoperative Subpleural Lung Tumor Margin Visualization Using Indocyanine Green (ICG) Inhalation

Surgical resection is the preferred treatment for early-stage non–small cell lung cancer, but defining the tumor margin during surgery is challenging. This video illustrates how inhalation of ICG in a rabbit lung tumor model facilitates intraoperative subpleural tumor margin visualization and tumor resection. Anesthetized rabbits inhaled nebulized ICG, and the distribution was visualized during open chest surgery using a near-infrared fluorescence imaging system; ICG localizes in normal tissue. Click the Related Article link for complete details.