Mitral annular disjunction (MAD), a separation between the mitral valve hinge point and the left ventricular (LV) myocardium, is being studied as a possible marker or substrate for ventricular arrhythmia and sudden cardiac death.
This video shows the finding on parasternal long-axis view of an echocardiogram in a patient with Marfan syndrome.
In a cohort study of patients with Marfan syndrome, MAD was associated with occurrence of arrhythmic events, a higher need for mitral valve intervention, and, in patients with extensive MAD, more aortic events.
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