This video shows the use of carcinoembryonic antigen–related cell adhesion molecule type 5 (CEACAM5) receptor–targeted intraoperative molecular imaging (SGM-101; Surgimab) on pulmonary nodules in 2 patients who presented with concerning lesions and elevated serum carcinoembryonic antigen (CEA) levels. In patient 1, SGM-101 identified 1 nodule in vivo and ex vivo by fluorescence microscopy. Nodule 2 was visualized in vivo but did not demonstrate any fluorescence in vivo or ex vivo. Nodule 1 was confirmed to be a metastatic lesion associated with primary pathology, whereas nodule 2 was a lymphoid aggregate. Similar observations were noted in patient 2, where serum CEA levels were elevated and demonstrated excellent fluorescence in vivo and ex vivo and on histologic assessment.
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