Use of CEACAM5 Receptor–Targeted Intraoperative Molecular Imaging to Detect Lung Cancer

This video shows the use of carcinoembryonic antigen–related cell adhesion molecule type 5 (CEACAM5) receptor–targeted intraoperative molecular imaging (SGM-101; Surgimab) on pulmonary nodules in 2 patients who presented with concerning lesions and elevated serum carcinoembryonic antigen (CEA) levels. In patient 1, SGM-101 identified 1 nodule in vivo and ex vivo by fluorescence microscopy. Nodule 2 was visualized in vivo but did not demonstrate any fluorescence in vivo or ex vivo. Nodule 1 was confirmed to be a metastatic lesion associated with primary pathology, whereas nodule 2 was a lymphoid aggregate. Similar observations were noted in patient 2, where serum CEA levels were elevated and demonstrated excellent fluorescence in vivo and ex vivo and on histologic assessment. Click the Related Article link for full details.